The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer

Table 4 Cox regression model analyses of the gene expression levels in association with RFS of breast cancer patients

	RFS
Variable	HR	95% CI	P value
miR-10a > 0.53 V.S miR-10a≦0.53	2.31	1.00 ~ 5.32	0.0503
miR-10b > 0.67 V.S miR-10b≦0.67	3.96	1.21 ~ 12.98	0.0231
RUNX2 > 3.05 V.S RUNX2≦3.05	3.02	1.50 ~ 6.07	0.0020
Number of overexpressing genes
0	1.00
1	2.80	0.30 ~ 25.77	0.3642
2	4.99	0.65 ~ 38.12	0.1212
3	12.37	1.62 ~ 94.55	0.0153
Additive model of gene overexpression	2.25	1.44 ~ 3.52	0.0004

Adjusted for age.
RFS: relapse-free survival, HR: Hazard ratio, CI: confidence interval, Gene overexpression: the expression level of an individual gene in tumor tissue normalized to adjacent non-tumor tissue from the same patient was categorized as “overexpression” by using the cutoff value determined from the ROC curve.
Bold face: statistical significant (P value < 0.05).

ISSN: 1479-5876