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Table 4 Cox regression model analyses of the gene expression levels in association with RFS of breast cancer patients

From: The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer

  RFS
Variable HR 95% CI P value
miR-10a > 0.53 V.S miR-10a0.53 2.31 1.00 ~ 5.32 0.0503
miR-10b > 0.67 V.S miR-10b0.67 3.96 1.21 ~ 12.98 0.0231
RUNX2 > 3.05 V.S RUNX23.05 3.02 1.50 ~ 6.07 0.0020
Number of overexpressing genes    
0 1.00   
1 2.80 0.30 ~ 25.77 0.3642
2 4.99 0.65 ~ 38.12 0.1212
3 12.37 1.62 ~ 94.55 0.0153
Additive model of gene overexpression 2.25 1.44 ~ 3.52 0.0004
  1. Adjusted for age.
  2. RFS: relapse-free survival, HR: Hazard ratio, CI: confidence interval, Gene overexpression: the expression level of an individual gene in tumor tissue normalized to adjacent non-tumor tissue from the same patient was categorized as “overexpression” by using the cutoff value determined from the ROC curve.
  3. Bold face: statistical significant (P value < 0.05).