The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer

Table 3 The relationship between overexpression of individual gene or joint effects of miR-10a, miR-10b, and RUNX2 with prognosis in breast cancer patients

	Relapse
	No	Yes
Variable	Number (%)	Number (%)	P-value	OR	95% CI	P value
miR-10a			0.0424
≦0.53	27 (79.4%)	7 (20.6%)		1.00
>0.53	44 (59.5%)	30 (40.5%)		2.83	1.05 ~ 7.68	0.0407
miR-10b			0.0043
≦0.67	24 (88.9%)	3 (11.1%)		1.00
>0.67	47 (58.0%)	34 (42.0%)		5.37	1.46 ~ 19.81	0.0116
RUNX2			0.0037
≦3.05	51 (76.1%)	16 (23.9%)		1.00
>3.05	20 (48.8%)	21 (51.2%)		3.55	1.47 ~ 8.58	0.0048
Number of overexpressing genes			0.0021
0	16 (94.9%)	1 ( 5.8%)		1.00
1	11 (73.3%)	4 (26.7%)		3.30	0.30 ~ 36.29	0.3288
2	32 (68.1%)	15 (31.9%)		6.01	0.71 ~ 50.83	0.0996
3	12 (41.4%)	17 (58.6%)		20.32	2.30 ~ 179.92	0.0068
Additive model of gene overexpression				2.66	1.50 ~ 4.75	0.0009

OR: odds ratio, CI: confidence interval, Gene overexpression: the expression level of an individual gene in tumor tissue normalized to adjacent non-tumor tissue from the same patient was categorized as “overexpression” by using the cutoff value determined from the ROC curve.
ORs and 95% CIs were estimated in the logistic regression model, in which a group of dummy variables was used to represent different groups of patients showing different numbers of overexpressing genes.
Bold face: statistical significant (P value < 0.05).

ISSN: 1479-5876