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Table 3 The relationship between overexpression of individual gene or joint effects of miR-10a, miR-10b, and RUNX2 with prognosis in breast cancer patients

From: The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer

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No Yes  
Variable Number (%) Number (%) P-value OR 95% CI P value
miR-10a    0.0424    
0.53 27 (79.4%) 7 (20.6%)   1.00   
>0.53 44 (59.5%) 30 (40.5%)   2.83 1.05 ~ 7.68 0.0407
miR-10b    0.0043    
0.67 24 (88.9%) 3 (11.1%)   1.00   
>0.67 47 (58.0%) 34 (42.0%)   5.37 1.46 ~ 19.81 0.0116
RUNX2    0.0037    
3.05 51 (76.1%) 16 (23.9%)   1.00   
>3.05 20 (48.8%) 21 (51.2%)   3.55 1.47 ~ 8.58 0.0048
Number of overexpressing genes    0.0021    
0 16 (94.9%) 1 ( 5.8%)   1.00   
1 11 (73.3%) 4 (26.7%)   3.30 0.30 ~ 36.29 0.3288
2 32 (68.1%) 15 (31.9%)   6.01 0.71 ~ 50.83 0.0996
3 12 (41.4%) 17 (58.6%)   20.32 2.30 ~ 179.92 0.0068
Additive model of gene overexpression     2.66 1.50 ~ 4.75 0.0009
  1. OR: odds ratio, CI: confidence interval, Gene overexpression: the expression level of an individual gene in tumor tissue normalized to adjacent non-tumor tissue from the same patient was categorized as “overexpression” by using the cutoff value determined from the ROC curve.
  2. ORs and 95% CIs were estimated in the logistic regression model, in which a group of dummy variables was used to represent different groups of patients showing different numbers of overexpressing genes.
  3. Bold face: statistical significant (P value < 0.05).