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Table 2 Correlation of expression of miR-10a, miR-10b and RUNX2 with clinical parameters of breast cancer patients

From: The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer

 

miR-10a

miR-10b

RUNX2

Variable

Mean ± SD

Median (Range)

P valuea

P valueb

Mean ± SD

Median (Range)

P valuea

P valueb

Mean ± SD

Median (Range)

P valuea

P valueb

Tissue

            

Non-tumor

1.00 ± 0.00

1.00 (1.00 ~ 1.00)

Ref.

Ref.

1.00 ± 0.00

1.00 (1.00 ~ 1.00)

Ref.

Ref.

1.00 ± 0.00

1.00 (1.00 ~ 1.00)

Ref.

Ref.

Tumor

2.02 ± 0.28

1.19 (0.01 ~ 18.57)

0.0003 c

0.1318d

3.13 ± 0.42

1.73 (0.07 ~ 26.72)

<0.0001 c

<0.0001 d

522.43 ± 381.75

2.16 (0.01 ~ 37902.36)

0.1748c

<0.0001 d

ER

            

Negative

2.88 ± 0.53

1.61 (0.07 ~ 18.57)

Ref.

Ref.

4.32 ± 0.76

2.24 (0.08 ~ 26.72)

Ref.

Ref.

818.84 ± 789.26

3.64 (0.53 ~ 27902.36)

Ref.

Ref.

Positive

1.33 ± 0.23

0.86 (0.01 ~ 11.91)

0.0085

0.0026

2.18 ± 0.40

1.49 (0.07 ~ 20.34)

0.0148

0.0134

285.31 ± 276.77

1.43 (0.01 ~ 16612.71)

0.5260

<0.0001

Molecular subtypes

            

Luminal A

1.34 ± 0.25

0.84 (0.04 ~ 7.48)

0.0178

0.0012

2.16 ± 0.31

1.54 (0.11 ~ 6.68)

0.0303

0.0064

8.29 ± 6.45

1.47 (0.01 ~ 233.94)

0.8339

<0.0001

Luminal B

1.97 ± 0.41

1.35 (0.01 ~ 11.91)

0.0501

0.0305

3.22 ± 0.76

1.87 (0.07 ~ 20.34)

0.0965

0.0146

1466.29 ± 1077.31

2.02 (0.30 ~ 37902.36)

0.1846

0.0070

ER-, PR-, Her2+

1.96 ± 1.06

0.88 (0.07 ~ 18.57)

0.2294

0.0047

2.34 ± 0.98

0.92 (0.08 ~ 15.79)

0.0637

0.0067

14.06 ± 7.34

2.72 (0.54 ~ 127.12)

0.5935

0.2280

ER-, PR-, Her2-

3.63 ± 0.85

2.10 (0.37 ~ 13.55)

Ref.

Ref.

5.80 ± 1.51

5.49 (0.33 ~ 26.72)

Ref.

Ref.

9.78 ± 2.89

5.94 (1.17 ~ 50.56)

Ref.

Ref.

Relapse

            

No

1.83 ± 0.34

1.02 (0.04 ~ 18.57)

Ref.

Ref.

2.46 ± 0.40

1.36 (0.07 ~ 20.34)

Ref.

Ref.

5.53 ± 1.85

1.88 (0.26 ~ 127.12)

Ref.

Ref.

Yes

2.37 ± 0.48

1.35 (0.01 ~ 13.55)

0.3753

0.1002

4.42 ± 0.91

2.04 (0.08 ~ 26.72)

0.0578

0.0171

1514.33 ± 1105.78

3.46 (0.01 ~ 37902.36)

0.1809

0.0268

Outcomes

            

Alive

1.86 ± 0.27

1.10 (0.01 ~ 18.57)

Ref.

Ref.

2.92 ± 0.42

1.55 (0.07 ~ 26.72)

Ref.

Ref.

184.40 ± 166.24

2.07 (0.01 ~ 16612.71)

Ref.

Ref.

Dead

3.96 ± 1.32

2.03 (0.84 ~ 10.56)

0.0450

0.0270

5.77 ± 1.84

5.14 (1.91 ~ 17.88)

0.0723

0.0099

4747.89 ± 4736.36

7.02 (0.30 ~ 37902.36)

0.3676

0.1017

  1. ER: estrogen receptor, PR: progesterone receptor, HER2: HER2/neu, Ref.: reference group.
  2. The expression level of the indicated gene in tumor tissue as determined by qPCR was normalized to that of adjacent non-tumor tissue of the same patient (2-△△Ct) (see Methods for details).
  3. aP value for independent t-test.
  4. bP value for Wilcoxon rank-sum test.
  5. cP value for paired t-test.
  6. dP value for Wilcoxon signed-rank test.
  7. Bold face: statistical significant (P value < 0.05).
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Journal of Translational Medicine

ISSN: 1479-5876

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