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Table 2 Correlation of expression of miR-10a, miR-10b and RUNX2 with clinical parameters of breast cancer patients

From: The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer

  miR-10a miR-10b RUNX2
Variable Mean ± SD Median (Range) P valuea P valueb Mean ± SD Median (Range) P valuea P valueb Mean ± SD Median (Range) P valuea P valueb
Tissue             
Non-tumor 1.00 ± 0.00 1.00 (1.00 ~ 1.00) Ref. Ref. 1.00 ± 0.00 1.00 (1.00 ~ 1.00) Ref. Ref. 1.00 ± 0.00 1.00 (1.00 ~ 1.00) Ref. Ref.
Tumor 2.02 ± 0.28 1.19 (0.01 ~ 18.57) 0.0003 c 0.1318d 3.13 ± 0.42 1.73 (0.07 ~ 26.72) <0.0001 c <0.0001 d 522.43 ± 381.75 2.16 (0.01 ~ 37902.36) 0.1748c <0.0001 d
ER             
Negative 2.88 ± 0.53 1.61 (0.07 ~ 18.57) Ref. Ref. 4.32 ± 0.76 2.24 (0.08 ~ 26.72) Ref. Ref. 818.84 ± 789.26 3.64 (0.53 ~ 27902.36) Ref. Ref.
Positive 1.33 ± 0.23 0.86 (0.01 ~ 11.91) 0.0085 0.0026 2.18 ± 0.40 1.49 (0.07 ~ 20.34) 0.0148 0.0134 285.31 ± 276.77 1.43 (0.01 ~ 16612.71) 0.5260 <0.0001
Molecular subtypes             
Luminal A 1.34 ± 0.25 0.84 (0.04 ~ 7.48) 0.0178 0.0012 2.16 ± 0.31 1.54 (0.11 ~ 6.68) 0.0303 0.0064 8.29 ± 6.45 1.47 (0.01 ~ 233.94) 0.8339 <0.0001
Luminal B 1.97 ± 0.41 1.35 (0.01 ~ 11.91) 0.0501 0.0305 3.22 ± 0.76 1.87 (0.07 ~ 20.34) 0.0965 0.0146 1466.29 ± 1077.31 2.02 (0.30 ~ 37902.36) 0.1846 0.0070
ER-, PR-, Her2+ 1.96 ± 1.06 0.88 (0.07 ~ 18.57) 0.2294 0.0047 2.34 ± 0.98 0.92 (0.08 ~ 15.79) 0.0637 0.0067 14.06 ± 7.34 2.72 (0.54 ~ 127.12) 0.5935 0.2280
ER-, PR-, Her2- 3.63 ± 0.85 2.10 (0.37 ~ 13.55) Ref. Ref. 5.80 ± 1.51 5.49 (0.33 ~ 26.72) Ref. Ref. 9.78 ± 2.89 5.94 (1.17 ~ 50.56) Ref. Ref.
Relapse             
No 1.83 ± 0.34 1.02 (0.04 ~ 18.57) Ref. Ref. 2.46 ± 0.40 1.36 (0.07 ~ 20.34) Ref. Ref. 5.53 ± 1.85 1.88 (0.26 ~ 127.12) Ref. Ref.
Yes 2.37 ± 0.48 1.35 (0.01 ~ 13.55) 0.3753 0.1002 4.42 ± 0.91 2.04 (0.08 ~ 26.72) 0.0578 0.0171 1514.33 ± 1105.78 3.46 (0.01 ~ 37902.36) 0.1809 0.0268
Outcomes             
Alive 1.86 ± 0.27 1.10 (0.01 ~ 18.57) Ref. Ref. 2.92 ± 0.42 1.55 (0.07 ~ 26.72) Ref. Ref. 184.40 ± 166.24 2.07 (0.01 ~ 16612.71) Ref. Ref.
Dead 3.96 ± 1.32 2.03 (0.84 ~ 10.56) 0.0450 0.0270 5.77 ± 1.84 5.14 (1.91 ~ 17.88) 0.0723 0.0099 4747.89 ± 4736.36 7.02 (0.30 ~ 37902.36) 0.3676 0.1017
  1. ER: estrogen receptor, PR: progesterone receptor, HER2: HER2/neu, Ref.: reference group.
  2. The expression level of the indicated gene in tumor tissue as determined by qPCR was normalized to that of adjacent non-tumor tissue of the same patient (2-Ct) (see Methods for details).
  3. aP value for independent t-test.
  4. bP value for Wilcoxon rank-sum test.
  5. cP value for paired t-test.
  6. dP value for Wilcoxon signed-rank test.
  7. Bold face: statistical significant (P value < 0.05).