| |
Simple analysis
|
Multiple analysis
|
|---|
| |
HR
|
95% CI
|
p-value
|
HR
|
95% CI
|
p-value
|
|---|
|
Sex
| | | | | | |
|
Female
|
1
| | |
1
| | |
|
Male
|
1.41
|
1.08-1.84
|
0.01
|
1.68
|
1.28-2.19
|
0.0002
|
|
Age, median 74
| | | | | | |
|
<74
|
1
| | |
1
| | |
|
≥74
|
2.39
|
1.80-3.16
|
<0.0001
|
2.58
|
1.94-3.42
|
<0.0001
|
|
T category
| | | | | | |
|
T3
|
1
| | |
1
| | |
|
T4
|
1.99
|
1.43-2.78
|
0.0001
|
1.76
|
1.24-2.49
|
0.002
|
|
Malignancy grade
| | | | | | |
|
Medium + Low
|
1
| | | | | |
|
High*
|
1.22
|
0.88-1.69
|
0.24
| | | |
|
Localisation
| | | | | | |
|
Right
|
1
| | | | | |
|
Left
|
0.96
|
0.73-1.24
|
0.74
| | | |
|
Perforation
| | | | | | |
|
No
|
1
| | |
1
| | |
|
Yes
|
1.80
|
1.20-2.72
|
0.005
|
1.49
|
0.96-2.32
|
0.08
|
|
Fixation
| | | | | | |
|
No
|
1
| | |
1
| | |
|
Yes
|
1.60
|
1.17-2.18
|
0.004
|
1.26
|
0.89-1.78
|
0.20
|
|
Lymph nodes
| | | | | | |
|
≥12
|
1
| | | | | |
|
<12
|
1.06
|
0.82-1.39
|
0.64
| | | |
|
Neuronal invasion
| | | | | | |
|
No
|
1
| | | | | |
|
Yes
|
1.19
|
0.76-1.87
|
0.44
| | | |
|
Vascular invasion
| | | | | | |
|
No
|
1
| | |
1
| | |
|
Yes
|
1.60
|
1.12-2.30
|
0.01
|
1.47
|
1.02-2.11
|
0.04
|
|
MSI status
| | | | | | |
|
MSI
|
1
| | | | | |
|
MSS
|
0.92
|
0.69-1.24
|
0.59
| | | |
|
miRNA-126
| | | | | | |
|
<median
|
1
| | |
1
| | |
|
>median
|
0.75
|
0.57-0.98
|
0.03
|
0.76
|
0.58-1.00
|
0.051
|
|
MVD
| | | | | | |
|
<median
|
1
| | | | | |
|
>median
|
1.01
|
0.77-1.32
|
0.94
| | | |
- HR: hazard ratio; CI: confidence interval; MSI: microsatellite instability; MSS: microsatelite stable; miRNA-126: microRNA-126; MVD: microvessel density.
- *Including mucinous and sigillocellular adenocarcinomas.
- Significant p-values are highlighted in bold.
