Skip to main content

Table 3 Cox regression analysis, overall survival (n = 560 in the multiple analysis)

From: The prognostic value of microRNA-126 and microvessel density in patients with stage II colon cancer: results from a population cohort

  Simple analysis Multiple analysis
  HR 95% CI p-value HR 95% CI p-value
Sex       
Female 1    1   
Male 1.41 1.08-1.84 0.01 1.68 1.28-2.19 0.0002
Age, median 74       
<74 1    1   
≥74 2.39 1.80-3.16 <0.0001 2.58 1.94-3.42 <0.0001
T category       
T3 1    1   
T4 1.99 1.43-2.78 0.0001 1.76 1.24-2.49 0.002
Malignancy grade       
Medium + Low 1      
High* 1.22 0.88-1.69 0.24    
Localisation       
Right 1      
Left 0.96 0.73-1.24 0.74    
Perforation       
No 1    1   
Yes 1.80 1.20-2.72 0.005 1.49 0.96-2.32 0.08
Fixation       
No 1    1   
Yes 1.60 1.17-2.18 0.004 1.26 0.89-1.78 0.20
Lymph nodes       
≥12 1      
<12 1.06 0.82-1.39 0.64    
Neuronal invasion       
No 1      
Yes 1.19 0.76-1.87 0.44    
Vascular invasion       
No 1    1   
Yes 1.60 1.12-2.30 0.01 1.47 1.02-2.11 0.04
MSI status       
MSI 1      
MSS 0.92 0.69-1.24 0.59    
miRNA-126       
<median 1    1   
>median 0.75 0.57-0.98 0.03 0.76 0.58-1.00 0.051
MVD       
<median 1      
>median 1.01 0.77-1.32 0.94    
  1. HR: hazard ratio; CI: confidence interval; MSI: microsatellite instability; MSS: microsatelite stable; miRNA-126: microRNA-126; MVD: microvessel density.
  2. *Including mucinous and sigillocellular adenocarcinomas.
  3. Significant p-values are highlighted in bold.