Table 2 Cox regression analysis, recurrence free cancer specific survival (n = 560 in the multiple analysis)

Sex

Female

1

Male

1.16

0.81-1.67

0.41

Age, median 74

<74

1

≥74

1.14

0.80-1.64

0.47

T category

T3

1

1

T4

3.65

2.46-5.43

<0.0001

2.69

1.74-4.16

<0.0001

Malignancy grade

Medium + Low

1

1

High*

1.49

0.98-2.27

0.06

1.42

0.92-2.18

0.11

Localisation

Right

1

Left

1.12

0.78-1.60

0.54

Perforation

No

1

1

Yes

3.66

2.34-5.73

<0.0001

2.57

1.54-4.30

0.0003

Fixation

No

1

1

Yes

2.49

1.69-3.67

<0.0001

1.32

0.83-2.10

0.23

Lymph nodes

≥12

1

<12

0.85

0.59-1.22

0.37

Neuronal invasion

No

1

1

Yes

2.05

1.24-3.38

0.005

1.46

0.84-2.55

0.18

Vascular invasion

No

1

1

Yes

2.00

1.27-3.16

0.003

1.61

1.00-2.61

0.05

MSI status

MSI

1

MSS

1.39

0.90-2.15

0.14

miRNA-126

<median

1

1

>median

0.72

0.50-1.04

0.08

0.96

0.66-1.40

0.83

MVD

<median

1

>median

0.88

0.61-1.26

0.49