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Table 1 Patient characteristics according to miRNA-126 and MVD

From: The prognostic value of microRNA-126 and microvessel density in patients with stage II colon cancer: results from a population cohort

Parameter Number miRNA-126 p-value MVD p-value
  (n = 560) (%) (n = 560)   (n = 555)  
Median (95% CI)   Median (95% CI)
Sex      
Male 241 (43) 2.49 (2.38-2.59) 0.61 10.7 (10.3-11.0) 0.17
Female 319 (57) 2.47 (2.40-2.53)   10.3 (10.0-10.7)  
Age, median 74      
≥74 280 (50) 2.49 (2.42-2.56) 0.31 10.7 (10.3-11.0) 0.11
<74 280 (50) 2.44 (2.34-2.53)   10.3 (10.0-10.7)  
T category      
T4 73 (13) 2.20 (2.03-2.42) 0.0004 10.3 (10.0-11.3) 0.59
T3 487 (87) 2.50 (2.44-2.56)   10.3 (10.0-10.7)  
Malignancy grade      
High* 107 (19) 2.33 (2.17-2.48) 0.01 10.0 (9.3-10.7) 0.03
Medium + Low 453 (81) 2.49 (2.43-2.56)   10.7 (10.3-10.7)  
Localisation      
Right 286 (51) 2.48 (2.39-2.54) 0.45 10.3 (10.0-10.7) 0.75
Left 274 (49) 2.48 (2.38-2.56)   10.3 (10.0-10.7)  
Perforation      
Yes 49 (9) 2.36 (2.05-2.42) 0.003 11.0 (10.0-12.0) 0.19
No 511 (91) 2.49 (2.43-2.56)   10.3 (10.0-10.7)  
Fixation      
Yes 100 (18) 2.36 (2.12-2.47) 0.0009 10.7 (10.3-11.3) 0.15
No 460 (82) 2.50 (2.43-2.57)   10.3 (10.0-10.7)  
Lymph nodes a      
≥12 251 (45) 2.49 (2.39-2.54) 0.96 10.7 (10.0-11.0) 0.10
<12 306 (55) 2.47 (2.39-2.56)   10.3 (10.0-10.7)  
Neuronal invasion      
Yes 47 (8) 2.38 (2.16-2.59) 0.66 10.0 (9.0-10.7) 0.29
No 513 (92) 2.48 (2.42-2.53)   10.3 (10.3-10.7)  
Vascular invasion      
Yes 67 (12) 2.48 (2.31-2.65) 0.81 10.3 (10.0-11.0) 0.98
No 493 (88) 2.48 (2.42-2.53)   10.3 (10.0-10.7)  
MSI status      
MSI 159 (28) 2.30 (2.17-2.46) 0.003 10.3 (10.0-11.0) 0.83
MSS 401 (72) 2.53 (2.46-2.59)   10.3 (10.0-10.7)  
  1. CI: confidence interval; miRNA-126: microRNA-126; MSI: microsatelite instability; MSS: microsatelite stable; MVD: microvessel density.
  2. aNot assessed for all patients.
  3. *Including mucinous and sigillocellular adenocarcinomas.
  4. Significant p-values are highlighted in bold.