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Figure 5 | Journal of Translational Medicine

Figure 5

From: Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition

Figure 5

Response of vemurafenib-resistant melanoma cell lines to DCA. A, Metabolic profiles of two vemurafenib-resistant melanoma cell lines (ED-013-R1 and ED-196-R) compared with their parental cell lines (ED-013 and ED-196). The panels indicate the basal OCR and the changes during successive addition of oligomycin (1 μM), FCCP (1 μM), rotenone/antimycin (1 μM/1 μM) and 2-DG (100 mM). Data constitute 6 parallel measurements and are representative of three independent experiments. B, Relative cell growth of vemurafenib sensitive cell lines (ED-013, ED-071 and SK-MEL-28) and their vemurafenib resistant sub-cultures (denoted R1 and R2) after treatment with DCA (10 mM), vemurafenib (1 μM) or the combination for 96 hours. C, Relative ATP levels after treatment with DCA (IC50), vemurafenib (IC50) or the combination for 24 hours.

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