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Table 1 Stem cell therapy companies and their cell products in development

From: Advancing stem cell therapy from bench to bedside: lessons from drug therapies

Company name Cell types Therapeutic programs/product name Clinical area Reference
Aastrom Bioscience Autologous Multicellular therapy (Ixmyelocel-T) Cardiovascular disease [121]
Peripheral artery Diseases (PAD)
Cytomedix Autologous adult stem cells ALDHbr (autologous regenerative cell therapy utilizing proprietary ALDH Bright Cell technology to isolate biologically active pluri-potent stem cells for therapeutic use) Ischemic heart failure [122]
Ischemic Stroke
Critical limb ischemia
Peripheral artery Diseases (PAD)
Cytori Therapeutics Autologous adult adipose derived stem cells Celution 800/CRS system (The system automates and standardizes the extraction and concentration of patients own Adipose Derived Regenerative Cells (ADRCs) in a clinical setting, enabling real-time access to autologous medical grade cells ADRCs Acute MI [123]
Cardiac failure
Burn care
Regenerative cells produced utilizing proprietary Soft tissue injury
Orthopedics
Breast reconstruction
Sports medicine
Dendreon Autologous cellular immunotherapy Provenge (sipuleucel-T) Body's own immune cells are isolated and reprogrammed to attack advanced prostate cancer. Prostate cancer (asymptomatic/minimally symptomatic metastatic castrate) [124]
Fibrocell Science Autologous Fibroblasts Azficel-T s BLA Program Skin [125]
Intrexon Synthetic Biology Rare Disease Program (Autologous cellular product treat rare and serious skin and connective tissue diseases and conditions) Connective tissue diseases
Immuno cellular therapeutics Autologous dendritic cell ICT- 107 (newly diagnosed Glioblastoma) Glioblastoma multiforme [126]
ICT- 121 (Recurrent Glioblastoma) Ovarian cancer
ICT- 140 (Ovarian cancer) Cancer stem cells
Autologous dendritic cell based vaccines
Japan Tissue Engineering Company (J-TEC) Autologous cell Autologous cultured epidermis Burns [127]
Autologous cultured Cartilage Cartilage defects
Autologous cultured Corneal Epithelium (Tissue engineering using autologous cells) Corneal damage
Northwest Biotherapeutics Autologous dendritic cells DCVax technology (Autologous dendritic cell-based therapy) Glioblastoma multiforme (brain tumor) [128]
Prostate cancer
Pharmicell Autologous bone marrow derived MSCs Hearticellgram (Autologous bone marrow derived MSCs) Acute Myocardial Infarction [129]
Advanced Cell Technology Allogeneic adult stem cells hESC-derived cells Retinal Pigment Epithelial Cell Program for: Stargardt's macular dystropy (SMD) Retinal Degenerative Conditions [130]
Dry Age-Related Macular Degeneration (AMD) Blood and cardiovascular diseases
Hemangioblast (HG) Program for: Diseases and disorders of circulatory and vascular system
Athersys Allogeneic adult stem cells Multistem Inflammatory & Immune [131]
Neurological
Cardiovascular disease
Ulcerative colitis
Ischemic stroke
BioTime Clinical-grade human embryonic stem (hES) cell lines OpRegen (hESC-derived RPE cells for the treatment of macular degeneration) Age-related degenerative disease [132]
OPC1 (hESC-derived oligodendrocyte progenitors for spinal cord injury); Spinal cord injury
VAC1 (a dendritic cell-based vaccine for cancer based on the telomerase antigen) Neuroscience orthopedics blood and vascular diseases oncology
Medipost Allogeneic human umbilical cord blood and Umbilical Cord Blood derived Mesenchymal Stem Cells (hUCB-MSCs) Cartistem (cartilage defect) Cartilage defects [133]
Neurostem (neuro-degenerative disorders) Alzheimer's disease
Pneumostem (pulmonary disorders) Amyotrophic Lateral Sclerosis (ALS)
Promostem (early engraftment of donor hematopoietic stem cells (HSCs)) Stroke
Chronic lung disease (premature babies)
Mesoblast Allogeneic adult derived mesenchymal precursor cells (MPCs) Proprietary Mesenchymal stem cells lineage technology Systemic diseases with underlying inflammatory and immunologic etiology [134]
Mesenchymal stem cells (MSCs) Cardiac and vascular diseases
Dental pulp stem cells (DPSCs) Orthopedic diseases of spine
Hematopoietic stem cells (HSCs) Improving outcome of bone marrow transplantation
Neostem Autologous adult stem cells, Targeted Immuno Therapy Program Cancer treatment [135]
Allogeneic T cell Embryonic like stem cells & Progenitor Cells CD34 cell program Ischemic repair
T Regulatory Cell Program Immune modulation
VSEL (Very small embryonic like stem cells ) technology Tissue regeneration
NeuralStem Human hippocampus Neural Stem cells NSI-189 (a compound developed for oral administration for psychiatric and cognitive disorders) Amyotrophic Lateral Sclerosis (ALS) [136]
Traumatic brain injury
Alzheimer's disease
Osiris Therapeutics Autologous and Allogeneic Mesenchymal stem cells (MSCs) OvationOS (bone matrix designed for the filling of bony voids and to support bone repair and regeneration) Bone damage [137]
Soft tissues(cartilage and tendon) wound healing
Grafix ( Allogeneic MSCs in extracellular matrix)
Cartiform (3-dimensional architecture of hyaline cartilage that contains the necessary cellular and molecular components for articular cartilage repair, and is primed for mesenchymal stem cell (MSC) activity)
Pluristem therapeutics Allogeneic cells PLX (Placental expanded cells) Cardiovascular disease [138]
Orthopedic disease
Pulmonary diseases
Stemcells Allogeneic tissue derived adult stem cells and progenitor cells HuCNS-SC (human neural stem cells) Spinal cord injury [139]
hLEC (human liver engrafting cells) Peripheral artery Diseases (PAD)
Pelizaeus-Merzbacher Disease (PMD)
Age-related macular degeneration (AMD)
Tigenix Autologous and Allogeneic adult stem cells ChondroCelect (Autologous Chondrocytes) Cartilage defects [140]
eASCs (Allogeneic expanded stem cells extracted from adipose tissue ) Perianal fistulas
Rheumatois arthritis