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Table 1 Stem cell therapy companies and their cell products in development

From: Advancing stem cell therapy from bench to bedside: lessons from drug therapies

Company name

Cell types

Therapeutic programs/product name

Clinical area


Aastrom Bioscience


Multicellular therapy (Ixmyelocel-T)

Cardiovascular disease


Peripheral artery Diseases (PAD)


Autologous adult stem cells

ALDHbr (autologous regenerative cell therapy utilizing proprietary ALDH Bright Cell technology to isolate biologically active pluri-potent stem cells for therapeutic use)

Ischemic heart failure


Ischemic Stroke

Critical limb ischemia

Peripheral artery Diseases (PAD)

Cytori Therapeutics

Autologous adult adipose derived stem cells

Celution 800/CRS system (The system automates and standardizes the extraction and concentration of patients own Adipose Derived Regenerative Cells (ADRCs) in a clinical setting, enabling real-time access to autologous medical grade cells ADRCs

Acute MI


Cardiac failure

Burn care

Regenerative cells produced utilizing proprietary

Soft tissue injury


Breast reconstruction

Sports medicine


Autologous cellular immunotherapy

Provenge (sipuleucel-T) Body's own immune cells are isolated and reprogrammed to attack advanced prostate cancer.

Prostate cancer (asymptomatic/minimally symptomatic metastatic castrate)


Fibrocell Science

Autologous Fibroblasts

Azficel-T s BLA Program



Intrexon Synthetic Biology Rare Disease Program (Autologous cellular product treat rare and serious skin and connective tissue diseases and conditions)

Connective tissue diseases

Immuno cellular therapeutics

Autologous dendritic cell

ICT- 107 (newly diagnosed Glioblastoma)

Glioblastoma multiforme


ICT- 121 (Recurrent Glioblastoma)

Ovarian cancer

ICT- 140 (Ovarian cancer)

Cancer stem cells

Autologous dendritic cell based vaccines

Japan Tissue Engineering Company (J-TEC)

Autologous cell

Autologous cultured epidermis



Autologous cultured Cartilage

Cartilage defects

Autologous cultured Corneal Epithelium (Tissue engineering using autologous cells)

Corneal damage

Northwest Biotherapeutics

Autologous dendritic cells

DCVax technology (Autologous dendritic cell-based therapy)

Glioblastoma multiforme (brain tumor)


Prostate cancer


Autologous bone marrow derived MSCs

Hearticellgram (Autologous bone marrow derived MSCs)

Acute Myocardial Infarction


Advanced Cell Technology

Allogeneic adult stem cells hESC-derived cells

Retinal Pigment Epithelial Cell Program for: Stargardt's macular dystropy (SMD)

Retinal Degenerative Conditions


Dry Age-Related Macular Degeneration (AMD)

Blood and cardiovascular diseases

Hemangioblast (HG) Program for: Diseases and disorders of circulatory and vascular system


Allogeneic adult stem cells


Inflammatory & Immune



Cardiovascular disease

Ulcerative colitis

Ischemic stroke


Clinical-grade human embryonic stem (hES) cell lines

OpRegen (hESC-derived RPE cells for the treatment of macular degeneration)

Age-related degenerative disease


OPC1 (hESC-derived oligodendrocyte progenitors for spinal cord injury);

Spinal cord injury

VAC1 (a dendritic cell-based vaccine for cancer based on the telomerase antigen)

Neuroscience orthopedics blood and vascular diseases oncology


Allogeneic human umbilical cord blood and Umbilical Cord Blood derived Mesenchymal Stem Cells (hUCB-MSCs)

Cartistem (cartilage defect)

Cartilage defects


Neurostem (neuro-degenerative disorders)

Alzheimer's disease

Pneumostem (pulmonary disorders)

Amyotrophic Lateral Sclerosis (ALS)

Promostem (early engraftment of donor hematopoietic stem cells (HSCs))


Chronic lung disease (premature babies)


Allogeneic adult derived mesenchymal precursor cells (MPCs)

Proprietary Mesenchymal stem cells lineage technology

Systemic diseases with underlying inflammatory and immunologic etiology


Mesenchymal stem cells (MSCs)

Cardiac and vascular diseases

Dental pulp stem cells (DPSCs)

Orthopedic diseases of spine

Hematopoietic stem cells (HSCs)

Improving outcome of bone marrow transplantation


Autologous adult stem cells,

Targeted Immuno Therapy Program

Cancer treatment


Allogeneic T cell Embryonic like stem cells & Progenitor Cells

CD34 cell program

Ischemic repair

T Regulatory Cell Program

Immune modulation

VSEL (Very small embryonic like stem cells ) technology

Tissue regeneration


Human hippocampus Neural Stem cells

NSI-189 (a compound developed for oral administration for psychiatric and cognitive disorders)

Amyotrophic Lateral Sclerosis (ALS)


Traumatic brain injury

Alzheimer's disease

Osiris Therapeutics

Autologous and Allogeneic Mesenchymal stem cells (MSCs)

OvationOS (bone matrix designed for the filling of bony voids and to support bone repair and regeneration)

Bone damage


Soft tissues(cartilage and tendon) wound healing

Grafix ( Allogeneic MSCs in extracellular matrix)

Cartiform (3-dimensional architecture of hyaline cartilage that contains the necessary cellular and molecular components for articular cartilage repair, and is primed for mesenchymal stem cell (MSC) activity)

Pluristem therapeutics

Allogeneic cells

PLX (Placental expanded cells)

Cardiovascular disease


Orthopedic disease

Pulmonary diseases


Allogeneic tissue derived adult stem cells and progenitor cells

HuCNS-SC (human neural stem cells)

Spinal cord injury


hLEC (human liver engrafting cells)

Peripheral artery Diseases (PAD)

Pelizaeus-Merzbacher Disease (PMD)

Age-related macular degeneration (AMD)


Autologous and Allogeneic adult stem cells

ChondroCelect (Autologous Chondrocytes)

Cartilage defects


eASCs (Allogeneic expanded stem cells extracted from adipose tissue )

Perianal fistulas

Rheumatois arthritis