Table 1 Stem cell therapy companies and their cell products in development
From: Advancing stem cell therapy from bench to bedside: lessons from drug therapies
Company name | Cell types | Therapeutic programs/product name | Clinical area | Reference |
|---|---|---|---|---|
Aastrom Bioscience | Autologous | Multicellular therapy (Ixmyelocel-T) | Cardiovascular disease | [121] |
Peripheral artery Diseases (PAD) | ||||
Cytomedix | Autologous adult stem cells | ALDHbr (autologous regenerative cell therapy utilizing proprietary ALDH Bright Cell technology to isolate biologically active pluri-potent stem cells for therapeutic use) | Ischemic heart failure | [122] |
Ischemic Stroke | ||||
Critical limb ischemia | ||||
Peripheral artery Diseases (PAD) | ||||
Cytori Therapeutics | Autologous adult adipose derived stem cells | Celution 800/CRS system (The system automates and standardizes the extraction and concentration of patients own Adipose Derived Regenerative Cells (ADRCs) in a clinical setting, enabling real-time access to autologous medical grade cells ADRCs | Acute MI | [123] |
Cardiac failure | ||||
Burn care | ||||
Regenerative cells produced utilizing proprietary | Soft tissue injury | |||
Orthopedics | ||||
Breast reconstruction | ||||
Sports medicine | ||||
Dendreon | Autologous cellular immunotherapy | Provenge (sipuleucel-T) Body's own immune cells are isolated and reprogrammed to attack advanced prostate cancer. | Prostate cancer (asymptomatic/minimally symptomatic metastatic castrate) | [124] |
Fibrocell Science | Autologous Fibroblasts | Azficel-T s BLA Program | Skin | [125] |
Intrexon Synthetic Biology Rare Disease Program (Autologous cellular product treat rare and serious skin and connective tissue diseases and conditions) | Connective tissue diseases | |||
Immuno cellular therapeutics | Autologous dendritic cell | ICT- 107 (newly diagnosed Glioblastoma) | Glioblastoma multiforme | [126] |
ICT- 121 (Recurrent Glioblastoma) | Ovarian cancer | |||
ICT- 140 (Ovarian cancer) | Cancer stem cells | |||
Autologous dendritic cell based vaccines | ||||
Japan Tissue Engineering Company (J-TEC) | Autologous cell | Autologous cultured epidermis | Burns | [127] |
Autologous cultured Cartilage | Cartilage defects | |||
Autologous cultured Corneal Epithelium (Tissue engineering using autologous cells) | Corneal damage | |||
Northwest Biotherapeutics | Autologous dendritic cells | DCVax technology (Autologous dendritic cell-based therapy) | Glioblastoma multiforme (brain tumor) | [128] |
Prostate cancer | ||||
Pharmicell | Autologous bone marrow derived MSCs | Hearticellgram (Autologous bone marrow derived MSCs) | Acute Myocardial Infarction | [129] |
Advanced Cell Technology | Allogeneic adult stem cells hESC-derived cells | Retinal Pigment Epithelial Cell Program for: Stargardt's macular dystropy (SMD) | Retinal Degenerative Conditions | [130] |
Dry Age-Related Macular Degeneration (AMD) | Blood and cardiovascular diseases | |||
Hemangioblast (HG) Program for: Diseases and disorders of circulatory and vascular system | ||||
Athersys | Allogeneic adult stem cells | Multistem | Inflammatory & Immune | [131] |
Neurological | ||||
Cardiovascular disease | ||||
Ulcerative colitis | ||||
Ischemic stroke | ||||
BioTime | Clinical-grade human embryonic stem (hES) cell lines | OpRegen (hESC-derived RPE cells for the treatment of macular degeneration) | Age-related degenerative disease | [132] |
OPC1 (hESC-derived oligodendrocyte progenitors for spinal cord injury); | Spinal cord injury | |||
VAC1 (a dendritic cell-based vaccine for cancer based on the telomerase antigen) | Neuroscience orthopedics blood and vascular diseases oncology | |||
Medipost | Allogeneic human umbilical cord blood and Umbilical Cord Blood derived Mesenchymal Stem Cells (hUCB-MSCs) | Cartistem (cartilage defect) | Cartilage defects | [133] |
Neurostem (neuro-degenerative disorders) | Alzheimer's disease | |||
Pneumostem (pulmonary disorders) | Amyotrophic Lateral Sclerosis (ALS) | |||
Promostem (early engraftment of donor hematopoietic stem cells (HSCs)) | Stroke | |||
Chronic lung disease (premature babies) | ||||
Mesoblast | Allogeneic adult derived mesenchymal precursor cells (MPCs) | Proprietary Mesenchymal stem cells lineage technology | Systemic diseases with underlying inflammatory and immunologic etiology | [134] |
Mesenchymal stem cells (MSCs) | Cardiac and vascular diseases | |||
Dental pulp stem cells (DPSCs) | Orthopedic diseases of spine | |||
Hematopoietic stem cells (HSCs) | Improving outcome of bone marrow transplantation | |||
Neostem | Autologous adult stem cells, | Targeted Immuno Therapy Program | Cancer treatment | [135] |
Allogeneic T cell Embryonic like stem cells & Progenitor Cells | CD34 cell program | Ischemic repair | ||
T Regulatory Cell Program | Immune modulation | |||
VSEL (Very small embryonic like stem cells ) technology | Tissue regeneration | |||
NeuralStem | Human hippocampus Neural Stem cells | NSI-189 (a compound developed for oral administration for psychiatric and cognitive disorders) | Amyotrophic Lateral Sclerosis (ALS) | [136] |
Traumatic brain injury | ||||
Alzheimer's disease | ||||
Osiris Therapeutics | Autologous and Allogeneic Mesenchymal stem cells (MSCs) | OvationOS (bone matrix designed for the filling of bony voids and to support bone repair and regeneration) | Bone damage | [137] |
Soft tissues(cartilage and tendon) wound healing | ||||
Grafix ( Allogeneic MSCs in extracellular matrix) | ||||
Cartiform (3-dimensional architecture of hyaline cartilage that contains the necessary cellular and molecular components for articular cartilage repair, and is primed for mesenchymal stem cell (MSC) activity) | ||||
Pluristem therapeutics | Allogeneic cells | PLX (Placental expanded cells) | Cardiovascular disease | [138] |
Orthopedic disease | ||||
Pulmonary diseases | ||||
Stemcells | Allogeneic tissue derived adult stem cells and progenitor cells | HuCNS-SC (human neural stem cells) | Spinal cord injury | [139] |
hLEC (human liver engrafting cells) | Peripheral artery Diseases (PAD) | |||
Pelizaeus-Merzbacher Disease (PMD) | ||||
Age-related macular degeneration (AMD) | ||||
Tigenix | Autologous and Allogeneic adult stem cells | ChondroCelect (Autologous Chondrocytes) | Cartilage defects | [140] |
eASCs (Allogeneic expanded stem cells extracted from adipose tissue ) | Perianal fistulas | |||
Rheumatois arthritis |