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Table 3 Number of nucleated cells, NK cells, monocytes and DCs infused (per kg of recipient’s body weight) according to the mobilization regimen

From: Mobilization of healthy donors with plerixafor affects the cellular composition of T-cell receptor (TCR)-αβ/CD19-depleted haploidentical stem cell grafts

 

G-CSF alone

G-CSF + MZ

P value

Total NC

   

 Median

1.17x109/kg

0.71x109/kg

0.0002

 Range

0.33-2.99

0.28-1.6

 

NK cells

   

 Median

31.3x106/kg

16.8x106/kg

0.0016

 Range

1.8-176.8

2.8-55.9

 

NK-like T cells

   

 Median

3.64x106/kg

1.56x106/kg

0.0016

 Range

0.4-34.8

0.2-6.64

 

CD16- monocytes

   

 Median

312.2x106/kg

226.8x106/kg

0.34

 Range

15.9-729.8

28.5-667.0

 

CD16+ monocytes

   

 Median

74.9x106/kg

63.6x106/kg

0.46

 Range

1.5-231.7

8.3-169.6

 

Slan-DCs

   

 Median

1.40x106/kg

0.85x106/kg

0.0008

 Range

0.5-4.14

0.06-1.27

 

CD1c+ MDC1

   

 Median

0.84x106/kg

0.88x106/kg

0.88

 Range

0.1-13.1

0.04-9.66

 

CD303+ pDCs

   

 Median

4.12x106/kg

4.73x106/kg

0.82

 Range

0.72-13.66

0.61-22.9

 

CD141+ MDC2

   

 Median

3.74x106/kg

4.15x106/kg

0.55

 Range

0.36-14.5

0.33-22.4

 

CD304+ pDCs

   

 Median

3.8x106/kg

3.1x106/kg

0.78

 Range

0.2-13.0

0.2-14.7

 
  1. NC = nucleated cells; MZ = plerixafor (Mozobil®); MDC1 = type 1 myeloid DCs; MDC2 = type 2 myeloid DCs. Comparisons between groups were performed with the Mann-Whitney U test for unpaired determinations.
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Journal of Translational Medicine

ISSN: 1479-5876

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