Figure 8

TFPI-2 reduced OSCC metastasis in vivo. (A) IG- or TIG-transduced OC2 cells were intravenously injected into the tail veins of athymic BALB/c nude mice (n = 5 in the IG group; n = 7 in the TIG group). Forty days after tumor cell inoculation, the number of pulmonary metastatic nodules derived from circulating cells in each mouse was counted. The Mann-Whitney U test was used to compare the numbers of tumor nodules between groups. *, P = 0.023. (B) Representative photograph of lung tissues excised from the mice.