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Figure 1 | Journal of Translational Medicine

Figure 1

From: The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer

Figure 1

Regulatory networks of miRNAs and PI3K/AKT pathway in controlling EMT and cancer stemness in human tumors including endometrial cancer. Activation of PI3K/AKT signaling plays an essential role in promoting EMT and cancer stem cell phenotypes. Interactions between PI3K/AKT and other pathways regulate EMT/CSC. MiRNAs function as both upstream mediators and downstream effectors to affect PI3K/AKT pathway activities. References showing the regulatory interactions are indicated. Verified interactions in endometrial cancer were underlined.

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