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Table 4 Patients characteristics and outcome of 24 pets with advanced cancer treated with metronomic chemotherapy and alkalization

From: High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors

Patient Age Sex Tumor Prev. treatment Tumor stage Outcome (weeks)
Mixed breed 10 FS Metastatic Anal sac Ca (sublumbar lymph nodes) Surgery T0 N1 MX PR 40
Mixed breed 12 FS Metastatic Anal sac Ca (sublumbar lymph nodes) Surgery T0 N1 MX CR 56
Mixed breed 16 FS Thyroid Ca Biopsy T3B N0 MX PD
Cocker Spaniel 6 MC Liver Sarcoma Biopsy T2 N0 MX PR 30
Dachshund 13 MC Liver Ca Biopsy T2 N0 MX CR 90+
Golden retriever 14 MC Ruptured Surgery T3 N0 MX NED 72
Splenic HSA
Labrador retriever 12 MC Ruptured Surgery T3 N0 MX NED 34
Splenic HSA
Golden retriever 13 FS Recurring inflammatory mammary Ca Surgery T4 N0 MX CR 104+
Golden retriever 10 FS Recurring inflammatory mammary Ca Surgery T4 N0 MX PD
Boxer 10 FS Metastatic mammary Ca (axillary lymph node) Biopsy T3 N1 MX PR 32
Dachshund 13 MC Limb Sarcoma Biopsy T3 N0 MX CR 20
Labrador retriever 11 M Recurring Surgery T2 N0 MX NED 30
Neck Sarcoma
Mixed breed 13 FS Nasal sinus AdCa Biopsy T3 N0 MX PR 24+
Labrador 10 FS Nasal Sarcoma Electrochemotherapy T3 N0 MX PR 20+
Tibetan spaniel 11 M Nasal carcinoma Biopsy T3 N0 MX PR 8
Visla 10 M Nasal carcinoma Biopsy T2 N0 MX PR16+
Mixed breed 10 F Lingual SCC Biopsy T2 N1A MX PR 16+
Mixed breed 12 FS Lung carcinoma Biopsy T1 NX MX SD 16+
Mixed breed 13 F Lung carcinoma Biopsy T1 NX MX PR 12
German Shepherd 10 M Visceral histiocytosis Biopsy T3 N1 MX PD
German shepherd 9 M OSA Biopsy T2 NX MX PD
Rottweiler 8 M OSA Biopsy T2 NX MX SD 8+
DSH 10 FS Nasal CSA Biopsy T2 N0 MX PR 100
DSH 10 FS Recurring anaplastic mammary carcinoma Surgery T4 N0 MX NED 54+
  1. The tumor stage refers at the moment of referral. HSA patients were referred after the surgical removal of their ruptured spleen and were the only patients without gross disease.
  2. Abbreviations: CA carcinoma, CR complete remission, CSA chondrosarcoma, F female, FS female spayed, M male, MC male castrated, NED no evidence of disease, OSA osteosarcoma, PD progressive disease, PR partial remission, SCC squamous cell carcinoma, SD stable disease.