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Table 2 Modified Eastern cooperative oncology group evaluation

From: High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors

Toxicity/Grade signs Duration
Hospitalization Days
0 0
1 1
2 2–3
3 4–5
4 ≥5
Neutropenia  
0 ≤500 neutrophils/mL
1 1,500–2,500 neutrophils/mL
2 ≥2,500 neutrophils/mL
3 500–999 neutrophils/mL
4 1,000–1,499 neutrophils/mL
Anorexia  
0 None
1 Inappetance
2 Anorexia ≤3 days duration
3 Anorexia >3 days but <5 days
4 Anorexia ≥5 days 10% weight loss
Vomiting  
0 None
1 Nausea
2 Sporadic, self-limiting
3 1–5 episodes per day, <2 days
4 6–10 episodes per day, hospitalized
Diarrhea  
0 None
1 Soft stools, responds to dietary modification
2 1–4 watery stools per day, <2 days
3 4–7 watery stools per day or >2 days
4 >7 watery stools per day or bloody,hospitalized
Infection  
0 None
1 No medication
2 Required medication
3 Debilitating
4 Threatening