Table 3 Summary of adverse events observed in study participants after initiation of the resveratrol intervention (n = 40)
Grade 1a | Grade 2 | Grade 3 | Grade 4 | |
|---|---|---|---|---|
Blood disorders | ||||
Anemia | 1b | 0 | 0 | 0 |
Ear disorders | ||||
Tinnitus | 1 | 0 | 0 | 0 |
Eye disorders | ||||
Dry eye | 1 | 0 | 0 | 0 |
Gastrointestinal disorders | ||||
Diarrhea | 6 | 6 | 0 | 0 |
Dyspepsia | 2 | 1 | 0 | 0 |
Constipation | 2 | 1 | 0 | 0 |
Food poisoning | 0 | 3 | 0 | 0 |
Flatulence | 2 | 0 | 0 | 0 |
Abdominal pain | 0 | 1 | 0 | 0 |
Gastroesophageal reflux | 0 | 1 | 0 | 0 |
Nausea | 0 | 1 | 0 | 0 |
Vomiting | 0 | 1 | 0 | 0 |
Stomach pain | 0 | 1 | 0 | 0 |
Intestinal distress | 1 | 0 | 0 | 0 |
General disorders | ||||
Flu-like symptoms | 0 | 3 | 0 | 0 |
Irritability | 1 | 0 | 0 | 0 |
Immune system disorders | ||||
Allergic reaction | 0 | 1 | 0 | 0 |
Allergic rhinitis | 0 | 1 | 0 | 0 |
Infections | ||||
Upper respiratory infection | 0 | 5 | 0 | 0 |
Sinusitis | 0 | 3 | 0 | 0 |
Urinary tract infection | 0 | 1 | 0 | 0 |
Cold sore on lip | 1 | 1 | 0 | 0 |
Bronchial infection | 0 | 1 | 0 | 0 |
Cold sore in mouth | 0 | 1 | 0 | 0 |
Investigations | ||||
↑ Total cholesterol | 10 | 1 | 0 | 0 |
↑ LDL | 7 | 0 | 0 | 0 |
↑ Triglycerides | 4 | 2 | 0 | 0 |
↑ VLDL | 4 | 0 | 0 | 0 |
↑ Cholesterol/HDL ratio | 3 | 0 | 0 | 0 |
↓ HDL | 2 | 0 | 0 | 0 |
↑ non-HDL | 1 | 0 | 0 | 0 |
↑Alanine aminotransferase | 2 | 0 | 0 | 1 |
↑Aspartate aminotransferase | 1 | 0 | 0 | 1 |
Metabolism and nutrition disorders | ||||
↑ Fasting glucose | 4 | 0 | 0 | 0 |
Appetite change | 2 | 0 | 0 | 0 |
Hypokalemia | 1 | 0 | 0 | 0 |
Musculoskeletal and connective tissue disorders | ||||
Myalgia | 0 | 1 | 0 | 0 |
Back pain | 0 | 1 | 0 | 0 |
Neck pain | 0 | 1 | 0 | 0 |
Arthralgia | 0 | 1 | 0 | 0 |
Swollen knee | 0 | 1 | 0 | 0 |
Body aches | 1 | 0 | 0 | 0 |
Leg pain | 1 | 0 | 0 | 0 |
Neoplasms | ||||
Ganglion cyst | 1 | 0 | 0 | 0 |
Nervous system disorders | ||||
Headache | 4 | 3 | 0 | 0 |
Vivid dreams | 2 | 0 | 0 | 0 |
Dysesthesia | 1 | 0 | 0 | 0 |
Dysgeusia | 1 | 0 | 0 | 0 |
Weird dreams | 1 | 0 | 0 | 0 |
Psychiatric disorders | ||||
Insomnia | 1 | 1 | 0 | 0 |
Renal and urinary disorders | ||||
Urinary incontinence | 0 | 1 | 0 | 0 |
Bladder spasm | 1 | 0 | 0 | 0 |
Urinary frequency | 1 | 0 | 0 | 0 |
Reproductive system disorders | ||||
Pelvic pain | 1 | 0 | 0 | 0 |
Respiratory, thoracic and mediastinal disorders | ||||
Dyspnea | 2 | 0 | 0 | 0 |
Laryngitis | 0 | 1 | 0 | 0 |
Sore throat | 0 | 1 | 0 | 0 |
Wheezing | 1 | 0 | 0 | 0 |
Skin and subcutaneous tissue disorders | ||||
Dry skin | 3 | 0 | 0 | 0 |
Rash, maculo-papular | 0 | 0 | 2 | 0 |
Rash, other | 1 | 0 | 0 | 0 |
Vascular disorders | ||||
Hot flashes | 3 | 1 | 0 | 0 |