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Table 3 Summary of adverse events observed in study participants after initiation of the resveratrol intervention (n = 40)

From: A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones

  Grade 1a Grade 2 Grade 3 Grade 4
Blood disorders
Anemia 1b 0 0 0
Ear disorders
Tinnitus 1 0 0 0
Eye disorders
Dry eye 1 0 0 0
Gastrointestinal disorders
Diarrhea 6 6 0 0
Dyspepsia 2 1 0 0
Constipation 2 1 0 0
Food poisoning 0 3 0 0
Flatulence 2 0 0 0
Abdominal pain 0 1 0 0
Gastroesophageal reflux 0 1 0 0
Nausea 0 1 0 0
Vomiting 0 1 0 0
Stomach pain 0 1 0 0
Intestinal distress 1 0 0 0
General disorders
Flu-like symptoms 0 3 0 0
Irritability 1 0 0 0
Immune system disorders
Allergic reaction 0 1 0 0
Allergic rhinitis 0 1 0 0
Infections
Upper respiratory infection 0 5 0 0
Sinusitis 0 3 0 0
Urinary tract infection 0 1 0 0
Cold sore on lip 1 1 0 0
Bronchial infection 0 1 0 0
Cold sore in mouth 0 1 0 0
Investigations
↑ Total cholesterol 10 1 0 0
↑ LDL 7 0 0 0
↑ Triglycerides 4 2 0 0
↑ VLDL 4 0 0 0
↑ Cholesterol/HDL ratio 3 0 0 0
↓ HDL 2 0 0 0
↑ non-HDL 1 0 0 0
↑Alanine aminotransferase 2 0 0 1
↑Aspartate aminotransferase 1 0 0 1
Metabolism and nutrition disorders
↑ Fasting glucose 4 0 0 0
Appetite change 2 0 0 0
Hypokalemia 1 0 0 0
Musculoskeletal and connective tissue disorders
Myalgia 0 1 0 0
Back pain 0 1 0 0
Neck pain 0 1 0 0
Arthralgia 0 1 0 0
Swollen knee 0 1 0 0
Body aches 1 0 0 0
Leg pain 1 0 0 0
Neoplasms
Ganglion cyst 1 0 0 0
Nervous system disorders
Headache 4 3 0 0
Vivid dreams 2 0 0 0
Dysesthesia 1 0 0 0
Dysgeusia 1 0 0 0
Weird dreams 1 0 0 0
Psychiatric disorders
Insomnia 1 1 0 0
Renal and urinary disorders
Urinary incontinence 0 1 0 0
Bladder spasm 1 0 0 0
Urinary frequency 1 0 0 0
Reproductive system disorders
Pelvic pain 1 0 0 0
Respiratory, thoracic and mediastinal disorders
Dyspnea 2 0 0 0
Laryngitis 0 1 0 0
Sore throat 0 1 0 0
Wheezing 1 0 0 0
Skin and subcutaneous tissue disorders
Dry skin 3 0 0 0
Rash, maculo-papular 0 0 2 0
Rash, other 1 0 0 0
Vascular disorders
Hot flashes 3 1 0 0
  1. aGraded using CTCAE version 4.0.
  2. bNumber of subjects experienced the event.