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Table 3 Summary of adverse events observed in study participants after initiation of the resveratrol intervention (n = 40)

From: A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones

 

Grade 1a

Grade 2

Grade 3

Grade 4

Blood disorders

Anemia

1b

0

0

0

Ear disorders

Tinnitus

1

0

0

0

Eye disorders

Dry eye

1

0

0

0

Gastrointestinal disorders

Diarrhea

6

6

0

0

Dyspepsia

2

1

0

0

Constipation

2

1

0

0

Food poisoning

0

3

0

0

Flatulence

2

0

0

0

Abdominal pain

0

1

0

0

Gastroesophageal reflux

0

1

0

0

Nausea

0

1

0

0

Vomiting

0

1

0

0

Stomach pain

0

1

0

0

Intestinal distress

1

0

0

0

General disorders

Flu-like symptoms

0

3

0

0

Irritability

1

0

0

0

Immune system disorders

Allergic reaction

0

1

0

0

Allergic rhinitis

0

1

0

0

Infections

Upper respiratory infection

0

5

0

0

Sinusitis

0

3

0

0

Urinary tract infection

0

1

0

0

Cold sore on lip

1

1

0

0

Bronchial infection

0

1

0

0

Cold sore in mouth

0

1

0

0

Investigations

↑ Total cholesterol

10

1

0

0

↑ LDL

7

0

0

0

↑ Triglycerides

4

2

0

0

↑ VLDL

4

0

0

0

↑ Cholesterol/HDL ratio

3

0

0

0

↓ HDL

2

0

0

0

↑ non-HDL

1

0

0

0

↑Alanine aminotransferase

2

0

0

1

↑Aspartate aminotransferase

1

0

0

1

Metabolism and nutrition disorders

↑ Fasting glucose

4

0

0

0

Appetite change

2

0

0

0

Hypokalemia

1

0

0

0

Musculoskeletal and connective tissue disorders

Myalgia

0

1

0

0

Back pain

0

1

0

0

Neck pain

0

1

0

0

Arthralgia

0

1

0

0

Swollen knee

0

1

0

0

Body aches

1

0

0

0

Leg pain

1

0

0

0

Neoplasms

Ganglion cyst

1

0

0

0

Nervous system disorders

Headache

4

3

0

0

Vivid dreams

2

0

0

0

Dysesthesia

1

0

0

0

Dysgeusia

1

0

0

0

Weird dreams

1

0

0

0

Psychiatric disorders

Insomnia

1

1

0

0

Renal and urinary disorders

Urinary incontinence

0

1

0

0

Bladder spasm

1

0

0

0

Urinary frequency

1

0

0

0

Reproductive system disorders

Pelvic pain

1

0

0

0

Respiratory, thoracic and mediastinal disorders

Dyspnea

2

0

0

0

Laryngitis

0

1

0

0

Sore throat

0

1

0

0

Wheezing

1

0

0

0

Skin and subcutaneous tissue disorders

Dry skin

3

0

0

0

Rash, maculo-papular

0

0

2

0

Rash, other

1

0

0

0

Vascular disorders

Hot flashes

3

1

0

0

  1. aGraded using CTCAE version 4.0.
  2. bNumber of subjects experienced the event.