Biochemical and inflammatory biomarkers in ischemic stroke: translational study between humans and two experimental rat models

Table 4 Models of stroke: correlations between biochemical markers, functional evaluation, volume of infarct and cell death

Correlations: values of spearman R	IL-6		TNF-α		Glutamate
	IL-6 3h	IL-6 72h	TNF-α 3h	TNF-α 72h	Glu 3h	Glu 72 h
Clinical score pre-euthanasia (72 h)	0.171	−0.600	0.348	−0.522	0.429	0.388
Clinical score pre-euthanasia (72 h)	0.507	0.169	0.676	0.338	−0.169	0.169
Volume of infarct as percentage of contralateral hemisphere	0.348	0.319	−0.088	−0.794	0.116	0.943***
	0.058	−0.087	0.522	0.000	−0.232	0.232
Cell death TUNEL in cortex	0.928***	−0.058	0.765*	−0.353	0.783*	0.486
TUNEL in striatum ^†	−0.714	−0.257	−0.714	−0.886**	0.086	−0.257
	−0.580	0.290	−0.294	−0.177	−0.348	0.429
	-	-	-	-	-	-

The upper line of each row corresponds to the embolic stroke (ES) model and the line below to the permanent middle cerebral artery occlusion (pMCAO) model. *P < 0.1; **P < 0.05; ***P < 0.01. Results with P< 0.1 are in bold
^†The pMCAO model presents infarctions affecting the cortex but not the striatum.

ISSN: 1479-5876