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Table 4 Models of stroke: correlations between biochemical markers, functional evaluation, volume of infarct and cell death

From: Biochemical and inflammatory biomarkers in ischemic stroke: translational study between humans and two experimental rat models

Correlations: values of spearman R IL-6 TNF-α Glutamate
  IL-6 3h IL-6 72h TNF-α 3h TNF-α 72h Glu 3h Glu 72 h
Clinical score pre-euthanasia (72 h) 0.171 −0.600 0.348 −0.522 0.429 0.388
0.507 0.169 0.676 0.338 −0.169 0.169
Volume of infarct as percentage of contralateral hemisphere 0.348 0.319 −0.088 −0.794 0.116 0.943***
0.058 −0.087 0.522 0.000 −0.232 0.232
Cell death TUNEL in cortex 0.928*** −0.058 0.765* −0.353 0.783* 0.486
TUNEL in striatum −0.714 −0.257 −0.714 −0.886** 0.086 −0.257
−0.580 0.290 −0.294 −0.177 −0.348 0.429
- - - - - -
  1. The upper line of each row corresponds to the embolic stroke (ES) model and the line below to the permanent middle cerebral artery occlusion (pMCAO) model. *P < 0.1; **P < 0.05; ***P < 0.01. Results with P< 0.1 are in bold
  2. The pMCAO model presents infarctions affecting the cortex but not the striatum.
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