Cancer
|
Bladder cancer cells
|
↓cell proliferation
|
n.d.
|
[75]
|
|
Breast cancer cells
|
↓cell proliferation
|
↓Cyclin D1, ↓Pin1,
|
[42],[43],[73],[75],[78],[79],[97]
|
| |
cell cycle arrest
|
↑c-jun, ↑H2O2
| |
| |
↓motility and invasiveness
| | |
| |
↑apoptosis
| | |
| |
↓DNA damage
| | |
|
Colon cancer cells
|
↓cell proliferation
|
↑H2O2
|
[42],[79]
|
| |
↑apoptosis
| | |
| |
↓motility and invasiveness
| | |
|
Glia cancer cells
|
↓motility
|
n.d.
|
[79]
|
|
Leukemia cells
|
↓cell proliferation
|
↑H2O2, ↑Cyclin D3,
|
[41],[72],[76]
|
| |
cell cycle arrest
|
↓CDK6
| |
| |
↑apoptosis
| | |
| |
↓DNA damage
| | |
|
Prostate cancer cells
|
↓cell proliferation
|
↑H2O2, ↑O2
−
|
[42],[44]
|
| |
↑apoptosis
| | |
|
Renal cancer cells
|
↓cell proliferation
|
n.d.
|
[79]
|
|
Thyroid cancer cells
|
cell cycle arrest
|
↓pAKT, ↓pERK
|
[80]
|
| |
↑apoptosis
| | |
|
Mice xenograft and albino hairless HOS:HR-mice
|
↓tumor growth
|
↓COX-2, ↓VEGF, ↓MMP-2/9/13
|
[81],[98]
|
Neurodegenerative disease
|
Brain hypoxia-reoxygenation
|
antioxidant ↓inflammation
|
↓lipid peroxidation, ↓PGE2, ↓IL1β, ↓NO
|
[92]
|
|
In vitro assay
|
↓Tau aggregation
|
n.d.
|
[90]
|
|
Sprague–Dawley rats
|
↓spinal cord injury
|
↓MDA activity
|
[91]
|
Skin disease
|
Albino hairless HOS:HR and C57BL/6J mice
|
↑UVB protection
|
↓MMP-13
|
[98],[99]
|
|
Balb/c mice
|
↑wound healing
|
↑VEGF
|
[95]
|