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Table 1 Controversial results on the capacity of R5 vs. X4 HIV-1 to replicate in primary CD4+ T lymphocytes in vitro

From: Asymmetric HIV-1 co-receptor use and replication in CD4+ T lymphocytes

CELL TYPE

STIMULATORY CONDITIONS

KEY REFERENCES

X4=R5

Lymphoid histo-cultures

none

Grivel et al. (40)

X4>R5

Lymphocyte tissue suspensions

none

Eckstein et al. (38)

Cord blood CD4+ T cells

PHA+IL-2

Sundaravaradan et al. (42)

PBMC-derived Th2 cell clones

Anti-CD3 mAb or Der P1+ IL-2

Maggi et al. (51) Annunziato et al. (52)

PBMC-derived Th2 cells

Anti-CD3+anti-CD28 mAb

Gosselin et al. (54)

R5>X4

PBMC-derived CD4+ T cells

none

Fiser et al. (44)

PBMC-derived Th1 cell clones

Anti-CD3 mAb or Der P1+ IL-2

Maggi et al. (51) Annunziato et al. (52)

Cord blood derived Th0, Th1, Th2 cells

Anti-CD3 mAb + IL-2

Vicenzi et al. (55)

PBMC-derived Th1 and Th2 cell clones

Anti-CD3 mAb+ IL-2

Vicenzi et al. (55)

PBMC-derived CD4+ T cells co-cultured with DC

Anti-CD3+anti-CD28 mAb

Yamamoto et al. (43)

Naïve and memory peripheral T cells

None

Bleul (25)

Recto-signoidal histocultures

None

Grivel et al. (40)

Cervico-vaginal histocultures

Culture medium

Saba et al. (41)

  1. * after normalization per number of CCR5 vs. CXCR4 expressing cells.