Figure 2
From: Asymmetric HIV-1 co-receptor use and replication in CD4+ T lymphocytes
Differential cell activation pathways triggered by R5 and X4 HIV-1 in CD4+ T cell. Both R5 and X4 HIV-1 gp120 Env engagement of CD4 and Co-R trigger signal transduction events leading to cell activation, host gene transcription, cell migration, survival and adhesion. R5 HIV-1 specifically induces adhesion via activation of FAK whereas X4 viruses modulate actin dynamics via activation of cofilin.