Figure 7

Expanded phenotype of canonical CD33⁺ human MDSC subset induced by tumor cell lines. Phenotype Expression of antigen presenting cell (left) and suppressor cell (right) markers on strongly suppressive (induced by HNSCC cell lines SCCL-MT1, SCC-4, CAL-27) versus non-suppressive (induced by SW 2224, RPMI 2650, or medium only) CD33⁺ myeloid cells as measured by flow cytometry. Median fluorescence above isotype control (data from 3 unique donors; mean shown for all three induction conditions (n = 9) +SEM). * indicates statistical significance, p <0.05, † indicates p = 0.59 for comparisons between suppressive cell and non-suppressive cells mean.