Figure 3

Tumor cell line-induced CD33⁺ MDSC inhibit proliferation of autologous, CD3/CD28-stimulated T cells through multiple mechanisms. Specific inhibitors of MDSC suppressive mechanisms ARG-1 and NOX2 mediate partial but incomplete reversal of suppression. * indicates statistical significant difference in mean T cell proliferation (mean shown + SEM, n ≥ 7 for each inhibitor, data from 2 independent experiments with similar results), p <0.05, by ANOVA followed by Tukey test for pairwise comparisons.