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Figure 1 | Journal of Translational Medicine

Figure 1

From: Induction of Th1Immune responses following laser ablation in a murine model of colorectal liver metastases

Figure 1

Tumor induced accumulation of CD3+ T cells and Kupffer cells. Liver sections from mice with CRC liver metastases 21 days post tumor induction (n >5) and from naive mice (n = 5) were immunostained for Kupffer cells (F4/80 antibody) and CD3+ T cells (anti-CD3+). Panels a and b: liver parenchyma from naïve mice stained with anti-CD3+ and F4/80 respectively. Panels c and d: liver parenchyma from tumor bearing mice stained with anti-CD3+ and F4/80 respectively Panels e and f: tumor sections depicting the tumor-liver parenchyma interface stained with anti-CD3+ and F4/80 respectively. Original magnification 200x Panels g and h: concentration of CD3+ T cells and Kupffer cells expressed as mean number of cells/mm2 ± SEM. 1, liver tissues from naïve animals; 2, liver tissues from tumor induced animals; 3, tissues from tumor-liver parenchyma interface. (CD3+ T; * P < 0.002 compared to naive, # P = 0.003 compared to naive, + P < 0.003 compared to tumor bearing liver.) (Kupffer cells; * P < 0.0003 compared to naive, # P < 0.0003 compared to naive, + P < 0.0003 compared to tumor bearing liver.)

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