Figure 5
Cyclin gene expression changes according to KIAA0247 expression and 5-FU treatment. Individual levels of 18S rRNA in the p53-null HCT116 cells (HCT116 p53-/-) quantified and normalized cyclin mRNA levels. Relative expressions of cyclin genes (as indicated) acquired by comparing normalized mRNA levels of cyclins with 40 μM 5-FU treatment to those in 5-FU-free conditions. shLuc, control cells without changing the expression of KIAA0247; overKIAA0247, KIAA0247-overexpressing cells. 5-FU, 5-fluorouracil. The asterisks indicate *p < 0.05 and **p < 0.01. Data are representative of three independent experimental repeats.