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Table 3 Cox analysis of the influence of LINE- 1 methylation on OS of stage IIIC CM patients

From: Methylation levels of the "long interspersed nucleotide element-1" repetitive sequences predict survival of melanoma patients

LINE1 CpG site # events/# patients* Extent methylation HR 95% CI; P value HRcont.§ 95% CI; P value
CpG1 13/21 <25.68 1**   1.51 1.06-2.16; 0.02
  17/21 ≥25.68 1.57 0.76-3.24; 0.22   
CpG2 12/21 <27.26 1   1.60 1.02-2.52; 0.04
  18/21 ≥27.26 2.12 1.01-4.44; 0.04   
CpG3 11/21 <40.46 1   1.49 1.06-2.09; 0.02
  19/21 ≥40.46 2.63 1.21-5.69;. 0.01   
  1. * number of patients who died (# events) and total number of patients in the group (# patients) are reported;
  2. † Patients were divided according to the % of methylation of the specified CpG site being <or ≥ the median % methylation measured in the examined patients' population;
  3. Cox proportional hazard method was used to examine the effect of LINE-1 methylation on OS. Results were presented as Hazard Ratios (HR) with corresponding 95% Confidence Intervals (CI);
  4. § LINE-1 methylation was also evaluated as continuous variable. The HR value is that of the LINE-1 methylation relative to an increase of 10%;
  5. ** set as reference.