Methylation levels of the

Table 2 OS of stage IIIC CM patients according to LINE- 1 methylation

LINE1 CpG site	# events/# patients*	Extent methylation^†	Median OS (95%CI)^‡	5 year OS (%)
CpG1	13/21	<25.68	24.3 (11.1-inf)	39
	17/21	≥25.68	15.3 (6.8-26.9)	16
CpG2	12/21	<27.26	31.5 (12.5-inf)	43
	18/21	≥27.26	11.5 (6.8-20.9)	13
CpG3	11/21	<40.46	31.9 (13.1-inf)	48
	19/21	≥40.46	11.5 (9.2-20.6)	7

* number of patients who died (# events) and total number of patients in the group (# patients) are reported;
† Patients were divided according to the % of methylation of the specified CpG site being < or ≥ the median % methylation measured in the examined patients' population;
^‡ Survival functions were calculated by the Kaplan-Meier method. Data are reported as Median OS in months, together with the corresponding 95% Confidence Intervals (CI).

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