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Table 2 OS of stage IIIC CM patients according to LINE- 1 methylation

From: Methylation levels of the "long interspersed nucleotide element-1" repetitive sequences predict survival of melanoma patients

LINE1 CpG site # events/# patients* Extent methylation Median OS (95%CI) 5 year OS (%)
CpG1 13/21 <25.68 24.3 (11.1-inf) 39
  17/21 ≥25.68 15.3 (6.8-26.9) 16
CpG2 12/21 <27.26 31.5 (12.5-inf) 43
  18/21 ≥27.26 11.5 (6.8-20.9) 13
CpG3 11/21 <40.46 31.9 (13.1-inf) 48
  19/21 ≥40.46 11.5 (9.2-20.6) 7
  1. * number of patients who died (# events) and total number of patients in the group (# patients) are reported;
  2. † Patients were divided according to the % of methylation of the specified CpG site being < or ≥ the median % methylation measured in the examined patients' population;
  3. Survival functions were calculated by the Kaplan-Meier method. Data are reported as Median OS in months, together with the corresponding 95% Confidence Intervals (CI).