Cell Line | BRAF/NRAS | Cell line characteristics |
---|---|---|
M249 | BRAFV600E |
Single agent vemurafenib: Highly sensitive Single agent metformin: Highly sensitive Combination: Slight synergy |
M249-AR4 |
BRAFV600E NRASQ61K |
Single agent vemurafenib: Resistant Single agent metformin: Intermediate sensitive Combination: Antagonistic |
M263 | BRAFV600E |
Single agent vemurafenib: Resistant Single agent metformin: Intermediate sensitive Combination: Slight synergy |
M308 | BRAFV600E |
Single agent vemurafenib: Resistant Single agent metformin: Highly sensitive Combination: Antagonistic |
SKMEL28 | BRAFV600E |
Single agent vemurafenib: Intermediate sensitive Single agent metformin: Resistant Combination: Antagonistic |
M207 | NRASQ61L |
Single agent vemurafenib: Resistant Single agent metformin: Resistant Combination: Slight synergy |
M296 | NRASQ61L |
Single agent vemurafenib: Resistant Single agent metformin: Highly sensitive Combination: Slight synergy |
SKMEL173 | NRASQ61K |
Single agent vemurafenib: Resistant Single agent metformin: Resistant Combination: Highly antagonistic |
WM1366 | NRAS |
Single agent vemurafenib: Resistant Single agent metformin: Highly sensitive Combination: Slight synergy |
M257 | Wild type |
Single agent vemurafenib: Resistant Single agent metformin: Intermediate sensitive Combination: Slight synergy |