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Figure 7 | Journal of Translational Medicine

Figure 7

From: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells

Figure 7

VX-680 induces mitochondrial depolarization and cellular caspase activation in NB4-R2 cells. (A) VX-680 treated NB4-R2 cells were stained with JC-1 probe and measured by flow cytometry. X- and Y-axes were indicative of monomer and aggregates, respectively. Data shown is a representative of three independent experiments. (B) NB4-R2 cells were collected, lysed and subjected to Western blot analysis with cleaved caspase-3, cleaved-PARP, pAkt-1 (Ser473), pGSK-3β (Ser9) specific antibodies. GAPDH was used as a loading control. Data shown is a representative of three independent experiments.

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