Figure 5From: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cellsVX-680 induces apoptosis of NB4-R2 cells by Annexin V/PI staining. NB4-R2 cells were treated with VX-680 at different concentrations for 24 hr and 48 hr. (A) Apoptotic cells were measured by Annexin V/PI staining. (B) Data summarized three independent experiments, **p < 0.01, ***p < 0.001, compared to control.Back to article page