Figure 4

VX-680 suppresses the proliferation of NB4-R2 cells and induces cell apoptosis. NB4-R2 cells were incubated with increasing doses of VX-680 (1, 2, 5 and 10 nM) for 24 hr and 48 hr. (A) Cell viability was measured by MTT assay. (B) Sub-G1 population was detected by flow cytometry. Data summarized three independent experiments, **p < 0.01, ***p < 0.001, compared to control.