Figure 2From: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cellsNB4-R2 cells are resistant to ATRA induced differentiation. (A) NB4 and NB4-R2 cells were treated with ATRA (1 μM) for 3 days, and CD11b-expressing population was measured by flow cytometry. (B) Data summarized three independent experiments, **p < 0.01, compared to control. (C) NB4 and NB4-R2 cells were treated with ATRA (1 μM), and the proliferation was measured by MTT assay. Data summarized three independent experiments, **p < 0.01, compared to control.Back to article page