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Figure 3 | Journal of Translational Medicine

Figure 3

From: The combined transduction of copper, zinc-superoxide dismutase and catalase mediated by cell-penetrating peptide, PEP-1, to protect myocardium from ischemia-reperfusion injury

Figure 3

Effect of PEP-1-SOD1 and PEP-1-CAT on LDH level and apoptosis rate. (A) Effect of PEP-1-SOD1 and PEP-1-CAT on LDH level. *P < 0.01 vs. control (CTL) group; $P < 0.01 vs H/R group; #P < 0.01 vs PEP-1-SOD1 group; @P < 0.01 vs PEP-1-CAT group (n = 5). (B) Effect of PEP-1-SOD1 and PEP-1-CAT on apoptosis of H9c2 cells under hypoxia-reoxygenation injury. H9c2 cells were pretreated with PEP-1-CAT for 6 h and/or PEP-1-SOD1 for 1 h. The cells were then placed in a normoxia environment for 27 h or in hypoxia chamber for 21 h followed by 6 h of reoxygenation. Apoptosis was measured by staining the cells with Annexin V and PI followed by Flow cytometry. The apoptosis rates are shown.

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