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Figure 5 | Journal of Translational Medicine

Figure 5

From: Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells

Figure 5

Curcumin synergistically enhanced the cytotoxic effects of DNR associated with down-regulation of Bcl-2. KG1a and Kausumi-1cells were exposed to different concentrations of curcumin, DNR, or their combination as indicated, for 48 h. (A, B) CI-effect plots and median-effect plots were generated using CalcuSyn software. The points a, b, and c represent CI values for the combinations 20, 40, and 80 μM curcumin with 0.1, 0.2, and 0.4 μg/ml DNR in a constant ratio, respectively. The CI values at ED50, ED75, ED90 were 0.667, 0.490, and 0.364 for KG1a cells and 0.529, 0.456, and 0.394 for Kasumi-1 cells, respectively. (C) Bcl-2 protein levels were determined by Western blotting assay. Three independent experiments were performed with similar results, and representative data are shown.

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