TY - JOUR AU - Petrone, Linda AU - Ammendolia, Maria G. AU - Cesolini, Armando AU - Caimi, Stefano AU - Superti, Fabiana AU - Giorgi, Colomba AU - Di Bonito, Paola PY - 2011 DA - 2011/05/18 TI - Recombinant HPV16 E7 assembled into particles induces an immune response and specific tumour protection administered without adjuvant in an animal model JO - Journal of Translational Medicine SP - 69 VL - 9 IS - 1 AB - The HPV16 E7 protein is both a tumour-specific and a tumour-rejection antigen, the ideal target for developing therapeutic vaccines for the treatment of HPV16-associated cancer and its precursor lesions. E7, which plays a key role in virus-associated carcinogenesis, contains 98 amino acids and has two finger-type structures which bind a Zn++ ion. The ability of an Escherichia coli-produced E7-preparation, assembled into particles, to induce protective immunity against a HPV16-related tumour in the TC-1-C57BL/6 mouse tumour model, was evaluated. SN - 1479-5876 UR - https://doi.org/10.1186/1479-5876-9-69 DO - 10.1186/1479-5876-9-69 ID - Petrone2011 ER -