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Figure 3 | Journal of Translational Medicine

Figure 3

From: Concomitant detection of IFNα signature and activated monocyte/dendritic cell precursors in the peripheral blood of IFNα-treated subjects at early times after repeated local cytokine treatments

Figure 3

Similarity of the modulation of PBMC gene expression between two doses of IFNα tested in combination with the HBV vaccine. Dendrogram of the unsupervised hierarchical clustering analysis of all samples collected in the HBV study. In (A) the analysis was restricted to the expression of the 161 genes differentially expressed between all "pre" (T0, T1m) and all "post" (T0+24, T1m+24) samples isolated from healthy donors receiving HBV vaccine in combination with 3 MU of IFNα (orange bar, Group C). In (B), the same analysis was conducted on the 176 genes differentially expressed between all "pre" (T0, T1m) and all "post" (T0+24, T1m+24) samples isolated from donors receiving HBV vaccine plus 1 MU of LE-IFNα (green bar, Group B). Blue bar: "pre" IFNα plus vaccine samples; red bar: "post" IFNα plus vaccine samples; black bar: "post" placebo plus vaccine samples.

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