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Figure 2 | Journal of Translational Medicine

Figure 2

From: Concomitant detection of IFNα signature and activated monocyte/dendritic cell precursors in the peripheral blood of IFNα-treated subjects at early times after repeated local cytokine treatments

Figure 2

Consistency of IFNα-induced modulation of PBMC gene expression profiles after each repeated administration of the cytokine. Dendrogram showing the unsupervised hierarchical clustering of all samples available for gene profiling analysis from the melanoma and HBV study. For Melanoma study (A,B), the analysis was restricted to the 156 genes differentially expressed between T0 and T2 samples (A) or the 179 genes differentially expressed between T42 and T44 samples (B). For HBV study (C, D), the analysis was restricted to the 249 genes differentially expressed between T0 and T0+24 (C) of samples isolated from Group C patients (receiving 3MU IFNα), or to the 70 genes differentially expressed between T1m and T1m+24 (D) of the same group. Blue bar: "pre" IFNα plus vaccine samples; red bar: "post" IFNα plus vaccine samples; black bar: "pre" and "post" placebo plus vaccine samples.

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