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Table 2 CYP450s responsible for M2 formation

From: Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes

 

CYP1A2

CYP2D6

CYP3A4

Km (μM)

100.0 ± 8.74

31.9 ± 1.23

27.8 ± 0.79

Vmax (pmol/min/pmol P450)

5.4 ± 0.094

2.7 ± 0.0052

0.024 ± 0.0021

Clint (μL/min/pmol P450)

0.054

0.085

0.00085

Nominal P450 Content in HLMs (pmol/mg)

45

10

108

Adjusted Clint (μL/min/mg)

2.43

0.85

0.0918

Percentage Adjusted Clint (%)

72.07

25.21

2.72