From: Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes
 | CYP1A2 | CYP2D6 | CYP3A4 |
---|---|---|---|
Km (μM) | 100.0 ± 8.74 | 31.9 ± 1.23 | 27.8 ± 0.79 |
Vmax (pmol/min/pmol P450) | 5.4 ± 0.094 | 2.7 ± 0.0052 | 0.024 ± 0.0021 |
Clint (μL/min/pmol P450) | 0.054 | 0.085 | 0.00085 |
Nominal P450 Content in HLMs (pmol/mg) | 45 | 10 | 108 |
Adjusted Clint (μL/min/mg) | 2.43 | 0.85 | 0.0918 |
Percentage Adjusted Clint (%) | 72.07 | 25.21 | 2.72 |