Figure 2From: Bioactivities of berberine metabolites after transformation through CYP450 isoenzymesBBR and its main phase-I metabolites in rat liver. Male Wistar rats (200-240 g, 8-week-old) were orally treated with BBR (200 mg/kg). Rat livers (n = 8) were removed 3 hrs later, followed by homogenization, cell lysate extraction and LC MS/MS detection. Presented are mean and sd of the 8 rats. Untreated control rats (n = 8) were used for comparison.Back to article page