Prognostic Impact of MiR-155 in Non-Small Cell Lung Cancer Evaluated by in Situ Hybridization

Table 1 Prognostic Clinicopathologic Variables as Predictors for Disease-Specific Survival in 335 NSCLC Patients (Univariate Analyses; Log-rank Test).

Characteristic	Patients (n)	Patients (%)	Median survival (months)	5-Year survival (%)	P
Age					0.34
≤65 years	156	47	83	55
>65 years	179	53	NR	60
Sex					0.20
Female	82	25	190	63
Male	253	75	83	56
Smoking					0.23
Never	15	5	19	43
Current	215	64	NR	60
Former	105	31	71	54
Performance status					0.013
ECOG 0	197	59	NR	63
ECOG 1	120	36	64	52
ECOG 2	18	5	25	33
Weight loss					0.71
<10%	303	90	127	58
>10%	32	10	98	57
Histology					0.028
SCC	191	57	NR	66
Adenocarcinoma	95	34	47	41
LCC	31	9	98	56
BAC	18		NR	71
Differentiation					<0.001
Poor	138	41	47	47
Moderate	144	43	190	64
Well	53	16	NR	68
Surgical procedure					0.004
Lobectomy + Wedge*	243	73	190	61
Pneumonectomy	92	27	37	47
Pathological stage					<0.001
I	157	47	190	71
II	136	41	61	51
IIIa	42	12	17	23
Tumor status					<0.001
1	85	25	190	74
2	188	56	84	57
3	62	19	25	36
Nodal status					<0.001
0	232	69	190	66
1	76	23	35	43
2	27	8	18	18
Surgical margins					0.29
Free	307	92	190	58
Not free	28	8	47	47
Vascular infiltration					<0.001
No	284	85	190	58
Yes	51	15	27	32

NR, not reached
* Wedge, n = 10
Abbreviations: SCC; squamous cell carcinoma; LCC, large-cell carcinoma; BAC, bronchioalveolar carcinoma

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