Table 3 Univariate and multivariate analysis of different prognostic factors in 123 patients with hepatocellular carcinoma (Cox Proportional Hazards Regression)
| Â | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
Variable | All cases | HR (95% CI) | Pvalue | HR (95% CI) | Pvalue |
Age (years) | Â | Â | 0.883 | Â | Â |
   ≤47.9a | 59 | 1.0 |  |  |  |
   >47.9 | 64 | 1.044 (0.588-1.853) |  |  |  |
Sex | Â | Â | 0.746 | Â | Â |
   Male | 107 | 1.153 (0.489-2.717) |  |  |  |
   Female | 16 | 1.0 |  |  |  |
Hepatitis history | Â | Â | 0.806 | Â | Â |
   Yes | 105 | 0.904 (0.405-2.021) |  |  |  |
   No | 18 | 1.0 |  |  |  |
AFP (ng/ml) | Â | Â | 0.000 | Â | 0.014 |
   ≤20 | 68 | 1.0 |  | 1.0 |  |
   >20 | 55 | 5.445 (2.852-10.395) |  | 2.573 (1.209-5.476) |  |
Liver cirrhosis | Â | Â | 0.807 | Â | Â |
   Yes | 87 | 1.0 |  |  |  |
   No | 36 | 1.082 (0.578-2.026) |  |  |  |
Tumor size (cm) | Â | Â | 0.000 | Â | 0.167 |
   ≤5 | 76 | 1.0 |  | 1.0 |  |
   >5 | 47 | 2.946 (1.640-5.290) |  | 1.595 (0.823-3.090) |  |
Tumor multiplicity | Â | Â | 0.000 | Â | 0.077 |
   Single | 85 | 1.0 |  | 1.0 |  |
   Multiple | 38 | 3.768 (2.108-6.735) |  | 1.790 (0.939-3.414) |  |
Differentiation | Â | Â | 0. 099 | Â | Â |
   Well-moderate | 85 | 1.0 |  |  |  |
   Poor-undifferentiated | 38 | 1.642 (0.911-2.958) |  |  |  |
Stage | Â | Â | 0.000 | Â | 0.363 |
   I-II | 61 | 1.0 |  | 1.0 |  |
   III -IV | 62 | 5.828 (2.722-12.480) |  | 1.571 (0.593-4.162) |  |
Vascular invasion | Â | Â | 0.000 | Â | 0.015 |
   Yes | 55 | 5.372 (2.724-10.595) |  | 2.724 (1.214-6.113) |  |
   No | 68 | 1.0 |  | 1.0 |  |
Relapse | Â | Â | 0.000 | Â | 0.321 |
   Yes | 42 | 2.885 (1.608-5.174) |  | 1.390 (0.725-2.666) |  |
   No | 81 | 1.0 |  | 1.0 |  |
p300 | Â | Â | 0.001 | Â | 0.021 |
   Low expression | 63 | 1.0 |  | 1.0 |  |
   High expression | 60 | 2.792 (1.533-5.087) |  | 2.077 (1.149-4.112) |  |
Ki67 | Â | Â | 0.089 | Â | Â |
   Low expression | 68 | 1.0 |  |  |  |
   High expression | 50 | 1.661 (0.925-2.982) |  |  |  |