Figure 3

The altered expression levels of p300 in HCC tissues by immunohistochemistry. A. and B. represented H&E staining for well-differentiated HCC (case 43) and poorly-differentiated HCC (case 37), respectively. C. Low expression of p300 was observed in a well-differentiated HCC case (case 43), in which less than 5% of tumor cells showed immunoreactivity of p300 protein in nuclei (×100). D. High expression of p300 was demonstrated in the poor-differentiated HCC case (case 37), in which more than 60% carcinoma cells showed immunoreactivity of p300 in nuclei (×100). Representative sites in HCC tissue with higher (inset, ×400) magnification were shown.