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Figure 2 | Journal of Translational Medicine

Figure 2

From: High expression of transcriptional coactivator p300 correlates with aggressive features and poor prognosis of hepatocellular carcinoma

Figure 2

The mRNA and protein expression of p300 in HCC and adjacent non-malignant liver tissues. A. Up-regulated expression of p300 mRNA was examined by RT-PCR in 3/4 HCC cases, when compared with adjacent non-malignant liver tissues. B. Up-regulated expression of p300 protein was detected by Western blotting in 4/4 HCC cases, when compared with adjacent non-malignant liver tissues. C. High expression of p300 was observed in a HCC (case 26), in which more than 90% tumor cells revealed positive immunostaining of p300 in nuclei (upper panel, × 100). D. A HCC case (case 81) demonstrated low expression of p300, in which less than 50% of tumor cells showed immunoreactivity of p300 protein in nuclei (upper panel, × 100). E. Nearly negative expression of p300 protein was demonstrated in a HCC case (case 57, upper panel, × 100). F. The adjacent non-malignant liver tissues of HCC case 26 showed nearly negative expression of p300 protein (upper panel, × 100). The lower panels indicated the higher magnification (× 400) from the area of the box in C., D., E. and F., respectively.

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