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Table 2 α-bisabolol cytotoxicity in acute leukemia cells and in their normal counterparts (% mean values ± SD according to α-bisabolol concentration).

From: Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute leukemia cells

μM α-bisabolol

20

40

80

160

IC50

p

Ph-B-ALL

14

37 ± 36

55 ± 37

87 ± 12

100

33 ± 15

<0.05

ns

Ph+B-ALL

14

2 ± 19

42 ± 28

81 ± 17

98 ± 2

46 ± 11

 

AML

14

10 ± 9

32 ± 21

72 ± 11

96 ± 4

54 ± 8

 

cluster 1

8

72 ± 24

94 ± 6

99 ± 1

100

14 ± 5

<0.05

<0.05

cluster 2

19

17 ± 9

44 ± 14

77 ± 15

97 ± 3

45 ± 7

 

cluster 3

15*

3 ± 3

14 ± 8

73 ± 14

98 ± 2

65 ± 5

 
 

17§

2 ± 3

14 ± 8

71 ± 16

97 ± 3

64 ± 5

 

CD34+

5

1 ± 2

22 ± 19

72 ± 35

98 ± 1

62 ± 9

ns

<0.05

CD33+my

5

2 ± 2

4 ± 3

40 ± 39

99 ± 1

95 ± 7

 
  1. *acute leukemia samples
  2. §15 acute leukemias plus CD34+ and CD33+my samples