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Table 2 α-bisabolol cytotoxicity in acute leukemia cells and in their normal counterparts (% mean values ± SD according to α-bisabolol concentration).

From: Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute leukemia cells

μM α-bisabolol 20 40 80 160 IC50 p
Ph-B-ALL 14 37 ± 36 55 ± 37 87 ± 12 100 33 ± 15 <0.05
ns
Ph+B-ALL 14 2 ± 19 42 ± 28 81 ± 17 98 ± 2 46 ± 11  
AML 14 10 ± 9 32 ± 21 72 ± 11 96 ± 4 54 ± 8  
cluster 1 8 72 ± 24 94 ± 6 99 ± 1 100 14 ± 5 <0.05
<0.05
cluster 2 19 17 ± 9 44 ± 14 77 ± 15 97 ± 3 45 ± 7  
cluster 3 15* 3 ± 3 14 ± 8 73 ± 14 98 ± 2 65 ± 5  
  17§ 2 ± 3 14 ± 8 71 ± 16 97 ± 3 64 ± 5  
CD34+ 5 1 ± 2 22 ± 19 72 ± 35 98 ± 1 62 ± 9 ns
<0.05
CD33+my 5 2 ± 2 4 ± 3 40 ± 39 99 ± 1 95 ± 7  
  1. *acute leukemia samples
  2. §15 acute leukemias plus CD34+ and CD33+my samples