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Figure 2 | Journal of Translational Medicine

Figure 2

From: Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients

Figure 2

A: correlation between NAb-status and neopterin serum levels; B: corelation between NAb-status and kyn/trp ratio. Both, neopterin levels (A) (p = 0.0003) and kyn/trp ratio (B) (p = 0.006) increased over time compared to baseline in each group. Although serum levels of neopterin and kyn/trp ratio showed no statistical difference at baseline between NAb-positive and NAb-negative patients, neopterin levels were significantly reduced in NAb-positive patients starting from month 9 onwards (p < 0.05); the same result was observed for kyn/trp ratio but only relatively to month 9 (p = 0.02).

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