Figure 3

Monocyte genes specifically induced by GM-CSF. Hierarchical clustering of the 98, 768, 756 and 467 genes induced by GM-CSF at 4 (a), 12 (b), 24 (c) and 48 (d) hours respectively (p-value < 0.001, FDR < 0.1) and the related GO analysis. The expression of each of these genes differed in GM-CSF treated monocytes compared to both time 0 monocytes and cells treated with Granulysin at the same time points. The hierarchical clustering was T0 corrected; the black bar indicates T0 monocytes, the fuchsia bar GM-CSF-treated monocytes, and the light blue bar Granulysin-treated monocytes. GO analyses were made with DAVID. The bars indicate -Log10 of the p-value of the overrepresentation of induced genes in each GO family. The green bars indicate down-regulated genes, while the red bars indicate up-regulated genes. The orange line indicates the threshold of statistical significance (p-value = 0.05)