Figure 2

Monocyte genes induced by both GM-CSF and 15 kDa granulysin. Hierarchical clustering of the 3191, 2416, 1534 and 1738 genes induced by both factors at 4 (a), 12 (b), 24 (c) and 48 (d) hours respectively (p-value < 0.001, FDR < 0.1) and the related GO analysis. The hierarchical clustering was T0 corrected; the black bar indicates T0 monocytes, the fuchsia bar GM-CSF-treated monocytes, and the light blue bar Granulysin-treated monocytes. GO analyses were made with DAVID. The bars indicate -Log10 of the p-value of the overrepresentation of genes induced in each GO family. Green bars indicate down-regulated genes, while red bars indicate up-regulated genes. The orange line indicates the threshold of statistical significance (p-value = 0.05)