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Table 3 Summary of clinical and molecular data for 44 Han Chinese subjects carrying the putative 12S rRNA mutations.

From: Frequency and spectrum of mitochondrial 12S rRNA variants in 440 Han Chinese hearing impaired pediatric subjects from two otology clinics

12S rRNA mutation GJB2 gene
mutation
Subjects Gender Audiometic configuration Age-at-onset
(years)
PTAa(dB)
right ear
PTA (dB)
left ear
Use of
drugs
Level of hearing
impairment
1555A > G polymorphism FE003-IV-1 M Slope 1 98 98 Yes Profound
1555A > G polymorphism FE007-IV-6 M Slope 2 100 100 Yes Profound
1555A > G polymorphism FE008-III-7 F Slope 10 58 78 No Severe
1555A > G polymorphism FE0128-IV-1 F Slope 2 102 98 Yes Profound
1555A > G polymorphism FE019-IV-1 F Slope 2 67 82 Yes Severe
1555A > G polymorphism FE020-III-15 M Slope 8 81 74 Yes Severe
1555A > G polymorphism FE036-III-1 M Slope 10 58 49 No Moderate
1555A > G polymorphism FE081-III-1 M Slope 16 50 56 Yes Moderate
1555A > G polymorphism FE122-III-2 F Slope 2 71 53 Yes Moderate
1555A > G polymorphism FE141-III-1 F Slope 2 24 30 No Mild
1555A > G polymorphism FE154-III-1 F Slope 18 61 60 No Moderate
1555A > G polymorphism FE160-III-1 F Slope 5 61 74 No Severe
1555A > G polymorphism FE163-III-3 M Flat 2 110 99 Yes Profound
1555A > G polymorphism FE300-II-12 F Slope 3 110 105 Yes Profound
1555A > G polymorphism FE304-II-2 F Slope 3 100 80 Yes Profound
1555A > G polymorphism FE317-III-10 M Slope 4 94 93 Yes Profound
1555A > G polymorphism FE350-III-1 F Flat 1 100 100 Yes Profound
1555A > G polymorphism NB038-III-1 M Flat 1 90 87 Yes Profound
1555A > G polymorphism NB048-III-2 F Slope 1 78 81 No Severe
1555A > G polymorphism NB052-III-2 F Flat 1 120 102 No Profound
1555A > G polymorphism NB076-III-1 M Flat 1 118 118 Yes Profound
1555A > G polymorphism NB078-III-2 F Flat 6 110 117 Yes Profound
1555A > G polymorphism NB079-III-1 M Flat 1 102 102 Yes Profound
1555A > G polymorphism NB094-III-2 F Flat 1 117 117 Yes Profound
1555A > G polymorphism NB111-III-2 F Slope 3 83 86 Yes Severe
1555A > G polymorphism NB126-III-2 F Slope 2 84 92 No Profound
1555A > G polymorphism NB137-III-1 F Slope 2 111 115 No Profound
1555A > G polymorphism ZX019-II-2 F Slope 5 59 62 Yes Moderate
1555A > G polymorphism ZX022-III-3 M Flat 2 101 102 Yes Profound
1555A > G polymorphism ZX025-III-14 M Flat 1 113 108 Yes Profound
1555A > G polymorphism ZX028-IV-1 F Slope 3 87 87 No Severe
1555A > G polymorphism ZX037-II-7 M Flat 5 30 27 No Mild
1555A > G polymorphism ZX047-III-1 M Slope 6 78 79 No Severe
1494C > T polymorphism FE247-III-1 M Flat 3 100 100 Yes Profound
1494C > T polymorphism NB133-II-1 M Slope 2 86 88 Yes Severe
1095T > C polymorphism FE312 F Slope 9 82 80 Yes Severe
1095T > C polymorphism NB021 M Slope 10 36 37 No Mild
1095T > C polymorphism NB067 M Flat 1 93 93 No Profound
1095T > C polymorphism NB100 F Flat 5 100 95 Yes Profound
747A > G polymorphism NS016-III-4 M Flat 1 100 80 Yes Profound
839A > G polymorphism NB005-III-1 F Flat 1 78 81 Yes Severe
1027A > G polymorphism FE239-II-1 M Slope 18 82 85 No Severe
1310C > T polymorphism NS071-IV-1 M Flat 1 91 92 No Profound
1413T > C 235DelC/299DelAT ZX039-IV-1 F Flat 1 114 111 No Profound
  1. a PTA: pure-tone audiometry; dB: decibel.