Table 2 Correlation between the clinicopathologic characteristics and expression of CDK4 protein in lung cancer
| Â | Â | CDK4 (%) | Â | |
|---|---|---|---|---|
Characteristics | n | High expression | Low expression | P |
Gender | Â | Â | Â | Â |
Male | 59 | 30(50.8%) | 29 (49.2%) | Â |
Female | 30 | 15(50%) | 15 (50%) | 1.000 |
Age(y) | Â | Â | Â | Â |
≥65 | 39 | 21 (53.8%) | 18 (46.2%) |  |
<65 | 50 | 24 (48%) | 26(52%) | 0.671 |
Smoking | Â | Â | Â | Â |
Yes | 38 | 23 (60.5%) | 15 (39.5%) | Â |
No | 51 | 22 (43.1) | 29 (56.9) | 0.135 |
Pathology classification | Â | Â | Â | Â |
squamous cell carcinoma | 39 | 15(38.5%) | 24(61.5%) | Â |
adenocarcinoma | 46 | 17(40%) | 29(60%) | Â |
small cell undifferentiated carcinoma | 4 | 3(75%) | 1(25%) | 0.047* |
Differentiated degree | Â | Â | Â | Â |
High | 25 | 9(36%) | 16(64%) | Â |
middle | 34 | 21(61.8%) | 13(38.2%) | Â |
Low or undifferentiated | 30 | 15(50%) | 15(50%) | 0.150* |
T classification | Â | Â | Â | Â |
T1+T2 | 71 | 32(45.1%) | 39(54.9%) | Â |
T3+T4 | 18 | 13(72.2%) | 5(27.8%) | 0.063 |
N classification | Â | Â | Â | Â |
N0+N1 | 58 | 23 (39.7%) | 35 (60.3%) | Â |
N2+N3 | 31 | 22 (71%) | 9 (29%) | 0.007 |
Distant metastasis | Â | Â | Â | Â |
Negative | 3 | 3 (100%) | 0 (0%) | Â |
Positive | 86 | 42 (48.8%) | 44 (51.2%) | 0.242 |
Clinical stage | Â | Â | Â | Â |
I~II | 55 | 21(38.2%) | 34(61.8%) | Â |
III~IV | 34 | 24 (70.6%) | 10(29.4%) | 0.004 |