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Figure 4 | Journal of Translational Medicine

Figure 4

From: Erratum to Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression

Figure 4

SERPINE1 mRNA level in fibroblasts under hypoxia (Figure 6). Transfection of miRNA-449a/b inhibitors additionally increased the hypoxia-induced SERPINE1 mRNA expression. The mean, minimum and maximum of calculations relative to reference gene POLR2A compared with non-transfected cells (= control) or cells transfected with negative control siRNA only (= negative control) cultured under hypoxia in 3 independent experiments are depicted. The miRNA-449 mimics showed virtually no down-regulation of SERPINE1 mRNA level.

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