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Table 3 Diagnostic accuracy of sFlt-1 and VEGF-A levels for septic shock development

From: Time-course of sFlt-1 and VEGF-A release in neutropenic patients with sepsis and septic shock: a prospective study

Biomarker
Time-point
sFlt-1 VEGF-A
Fever onset   
AUC * 0.61 (0.41-0.81); P = 0.81 0.58 (0.38-0.77); P = 0.47
48 hours after fever onset   
AUC * 0.87 (0.73-1.00); P < 0.01 0.76 (0.55-0.97); P = 0.02
  1. * AUC: area under ROC curve; sFlt-1 and VEGF-A thresholds correspond to the median value for each time point. AUC expressed with 95% confidence interval (CI95%)