Figure 3

sFlt-1 and VEGF-A levels in patients with FN. Combined analysis sFlt-1 and VEGF-A levels in patients with FN. Actual sFlt-1 and VEGF-A serum levels obtained at fever onset and after 48 hours are plotted simultaneously as well as median values for each marker at each time point (dotted lines). At fever onset, cases with non-complicated sepsis (empty circles) and septic shock (full circles) are spread evenly across the median values for both parameters (3a-b). After 48 hours, cases that evolved to septic shock seem to localize more frequently in the right upper quadrant (high VEGF-A and high sFlt-1) than cases with non-complicated sepsis, in which levels of both biomarkers change very little.