Study Title/Sponsor | NCT #/ # Enrolled/ Start Date | Condition | Description |
---|---|---|---|
Next Generation to Identify Genetic Causes of Disease in Patients Participating in NICHD Clinical Protocols NICHD | NCT01375543 100 June 2011 | Genetic diseases (pediatric) | Use of DNA samples to conduct exome and genome sequencing |
Feasibility Clinical Study of Targeted and Genome-Wide Sequencing University Health Network, Toronto | NCT01345513 100 March 2011 | Solid Tumors | Targeted and genome-wide sequencing of DNA to enable molecular characterization of tumors. |
Biomarkers in Tissue Samples from Patients with High-Risk Wilms Tumor NCI | NCT01118078 100 March 2010 | Kidney Cancer | Application of array-based methods and NGS to identify candidate molecular targets |
Whole Genome Medical Sequencing for Genome Discovery NHGRI | NCT01087320 100 Feb 2010 | Congenital Syndromes/ Genetic Disorders | Using genomic sequencing to identify genetic causes of disorders that are difficult to identify with existing techniques |
Studying DNA in Tumor Tissue Samples from Patients with Localized or Metastatic Osteosarcoma NCI | NCT01062438 99 Jan 2010 | Sarcoma | Genomic expression profile in osteosarcoma tumor samples using transcriptome sequencing |
Genetics of Congenital Heart Disease Nationwide Children's Hospital | NCT01192048 1000 Dec 2009 | Congenital Heart Disease | Direct sequencing and/or microarray, whole-genome array comparative genomic hybridization (CGH) |
Integrated Whole-Genome Analysis of Hematologic Disorders Stanford University | NCT01108159 100 Sept 2009 | Hematologic Diseases | Whole-genome analysis/high-throughput sequencing using blood, bone marrow and skin biopsy samples |
Study of Tissue Samples from Patients with Lymphoma NCI | NCT00952809 300 March 2009 | Lymphoma; Small Intestinal Cancer | Generation of genome-wide maps of the distribution of nucleosomes and histone modifications as assessed by high throughput sequencing (ChIP-Seq) |
Genetics of Endocrine Tumours Barts & The London NHS Trust | NCT00461188 150 March 2007 | Acromegaly | Tumor samples studied using candidate gene sequencing |
DNA Analysis of Tumor Tissue Samples from Patients with Diffuse Brain Stem Glioma St. Jude Children's Research Hospital | NCT00899834 30 June 2006 | Brain & CNS Tumors | Genome-wide expression of RNA in tumor samples using gene expression profiling. Direct sequencing analysis of tumor DNA |
ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study NHGRI | NCT00410241 2000 Dec 2006 | Cardiovascular Disease | Sequencing ~ 400 genes related to heart disease |
Laboratory Study of Lymphoblasts in Young Patients with High-Risk ALL NCI | NCT00896766 150 July 2006 | Leukemia | Pilot application of array-based methods and gene re-sequencing to identify candidate molecular targets for ALL |
Genome Expression in Lymphoma, Leukemia and Multiple Myeloma NCI | NCT00339963 3000 Nov 2001 | Lymphoma, Leukemia Multiple Myeloma | Participating centers send samples to the NCI for gene expression profiling, array-based comparative genomic hybridization and cancer gene re-sequencing. |